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Invitrogen

Procollagen I C-Peptide Polyclonal Antibody

View all (30) Collagen I antibodies

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Procollagen I C-Peptide Polyclonal Antibody

Product Details

PA5-145235

Applications
Tested Dilution
Publications

Western Blot (WB)

0.01-2 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

5-20 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated Human CTXI protein, E1207-A1218 (Accession #Q9NPZ5)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography, Protein A

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.05% Proclin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3092251

Target Information

Collagen I is a Type I collagen with a triple helix structure comprised of two alpha-1 chains and one alpha-2 chain. Collagen I is a member of group I collagen (fibril-forming collagen) found in most connective tissues, and is abundant in bone, cornea, dermis and tendon. Mutations in the COL1A2 gene encoding the alpha-2 chain are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in the COL1A2 gene which codes for the alpha-2 chain, however, tend to be less severe than mutations in the COL1A1 gene, reflecting the different role of alpha-2 chains in matrix integrity. Reciprocal translocations between chromosomes 17 and 22, where Collagen Type 1 genes and the gene for platelet derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: alpha 1 (I) chain propeptide; alpha 2 type I procollagen; alpha 2(I) procollagen; alpha 2(I)-collagen; alpha-1 collagen type 1; alpha-1 collagen type I; alpha-1 type I collagen; alpha-2 type I collagen; alpha1(I) procollagen; COL1; COL1A1; collagen 1 pro-alpha-2 chain; collagen alpha 1 chain type I; collagen alpha-1(I) chain preproprotein; collagen Col1-ColIII-1; collagen Col1-ColIII-2; collagen I, alpha-2 polypeptide; collagen of skin, tendon and bone, alpha-1 chain; collagen of skin, tendon and bone, alpha-2 chain; collagen, type I, alpha 1; collagen, type I, alpha 2; epididymis secretory sperm binding protein; pre-pro-alpha-2 type I collagen; pro-alpha-1 collagen type 1; Type I Collagen; type I proalpha 1; type I procollagen; type I procollagen alpha 1 chain; unnamed protein product

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Gene Aliases: CAFYD; EDSARTH1; EDSARTH2; EDSC; EDSCV; OI1; OI2; OI3; OI4

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UniProt ID: (Human) P02452, (Human) P08123

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Entrez Gene ID: (Human) 1277, (Human) 1278

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Function(s)
protease binding extracellular matrix structural constituent protein binding extracellular matrix structural constituent conferring tensile strength identical protein binding platelet-derived growth factor binding protein binding, bridging SMAD binding
Process(es)
skeletal system development blood vessel development transforming growth factor beta receptor signaling pathway Rho protein signal transduction regulation of blood pressure collagen fibril organization odontogenesis skin development skin morphogenesis animal organ development ossification osteoblast differentiation response to nutrient visual perception sensory perception of sound response to xenobiotic stimulus response to mechanical stimulus positive regulation of epithelial to mesenchymal transition positive regulation of cell migration response to nutrient levels response to estradiol response to insulin collagen biosynthetic process protein localization to nucleus tooth mineralization response to hydrogen peroxide response to peptide hormone cellular response to fibroblast growth factor stimulus positive regulation of transcription, DNA-templated response to steroid hormone embryonic skeletal system development system development response to cAMP response to hyperoxia cellular response to mechanical stimulus cellular response to retinoic acid cellular response to vitamin E cellular response to glucose stimulus cellular response to tumor necrosis factor cellular response to epidermal growth factor stimulus cellular response to transforming growth factor beta stimulus positive regulation of canonical Wnt signaling pathway response to fluoride cellular response to fluoride cellular response to acetaldehyde
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