Search
Invitrogen
Jagged1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-145347
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human JAG1 protein, Gly470-Thr834 (Accession #P78504)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography, Protein A
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% Proclin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
For immunocytochemistry the cells were formalin fixed.
Target Information
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: jagged 1; jagged canonical Notch ligand 1; jagged-1 protein; Notch ligand; putative; Serrate-1; unnamed protein product
Gene Aliases: ABE2; AGS; AGS1; AHD; AWS; CD339; CMT2HH; DCHE; Gena228; Gsfabe2; HJ1; Htu; JAGL1; Ozz; Ser-1
UniProt ID: (Human) P78504, (Mouse) Q9QXX0, (Rat) Q63722
Entrez Gene ID: (Human) 182, (Mouse) 16449, (Rat) 29146
angiogenesis
cell fate determination
negative regulation of cell-matrix adhesion
T cell mediated immunity
aortic valve morphogenesis
pulmonary valve morphogenesis
cardiac right ventricle morphogenesis
cell communication
Notch signaling pathway
nervous system development
regulation of gene expression
negative regulation of cell-cell adhesion
hemopoiesis
keratinocyte differentiation
negative regulation of cell migration
response to muramyl dipeptide
aorta morphogenesis
regulation of cell proliferation
myoblast differentiation
endothelial cell differentiation
negative regulation of cell differentiation
negative regulation of endothelial cell differentiation
positive regulation of Notch signaling pathway
positive regulation of transcription from RNA polymerase II promoter
animal organ development
system development
inner ear development
cardiac septum morphogenesis
pulmonary artery morphogenesis
cardiac neural crest cell development involved in outflow tract morphogenesis
endocardial cushion cell development
positive regulation of cardiac epithelial to mesenchymal transition
nephron development
glomerular visceral epithelial cell development
distal tubule development
loop of Henle development
neuronal stem cell population maintenance
negative regulation of stem cell differentiation
blood vessel remodeling
morphogenesis of an epithelium
morphogenesis of an epithelial sheet
organ morphogenesis
positive regulation of gene expression
tube morphogenesis
auditory receptor cell differentiation
camera-type eye development
positive regulation of cell differentiation
negative regulation of fat cell differentiation
positive regulation of myeloid cell differentiation
negative regulation of neuron differentiation
positive regulation of osteoblast differentiation
cell development
regulation of multicellular organismal process
ciliary body morphogenesis
sensory organ morphogenesis
regeneration
organ regeneration
wound healing
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support