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Invitrogen
Cytomegalovirus UL146 Polyclonal Antibody
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Product Details
PA5-149147
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Virus
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived recombinant viral CMV UL146/vCXC1
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Cytomegalovirus (CMV) UL146 is a gene encoded by human cytomegalovirus (HCMV), a member of the herpesvirus family that can cause significant disease in immunocompromised individuals and newborns. The UL146 gene is part of a cluster of genes that encode for viral chemokine-like proteins. UL146 specifically encodes a CXC chemokine, vCXCL1, which mimics human chemokines and can bind to chemokine receptors on host cells. This viral chemokine plays a crucial role in modulating the host immune response by attracting neutrophils to the site of infection. By doing so, UL146 can alter the local immune environment, potentially aiding the virus in evading immune detection and promoting viral dissemination. The activity of UL146 is significant in the context of HCMV pathogenesis, as it can contribute to the chronic inflammation and immune dysregulation associated with HCMV infections. Understanding the function and mechanisms of UL146 is essential for developing targeted antiviral therapies and improving strategies to manage HCMV-related diseases. Research into UL146 also provides broader insights into viral immune evasion tactics and the complex interactions between viruses and the host immune system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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