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Invitrogen
ULK3 Polyclonal Antibody
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FIGURE: 1 / 3
ULK3 Antibody (PA5-15397) in IHC (P)
Immunohistochemistry analysis of ULK3 in formalin-fixed and paraffin-embedded human testis tissue. Samples were incubated with ULK3 polyclonal antibody (Product # PA5-15397) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-15397
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 14-43 amino acids from the N-terminal region of human ULK3
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Purification
Size-exclusion - Dialysis, Ammonium sulfate precipitation
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with mouse based on sequence homology.
Target Information
ULK3 or unc-51-like kinase 3 is a member of the serine/threonine kinase family that is involved in the SHH signaling pathway as a positive regulator of GLI proteins. ULK3 enhances endogenous and over-expressed GLI transcriptional activity in cultured cells and alters its subcellular localization. Furthermore, ULK3 phosphorylates GLI proteins in vitro. ULK3 is widely expressed and its expression is higher in a number of tissues where SHH signaling is known to be active, again suggesting that ULK3 is involved in the SHH pathway as a positive regulator of GLI proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZP434C131; EC:2.7.11.1; FLJ90566; unnamed protein product
Gene Aliases: 1200015E14Rik
UniProt ID: (Human) Q6PHR2, (Mouse) Q3U3Q1
Entrez Gene ID: (Human) 25989, (Mouse) 71742
autophagosome assembly
mitophagy
autophagy
smoothened signaling pathway
regulation of autophagy
piecemeal microautophagy of nucleus
response to starvation
negative regulation of smoothened signaling pathway
positive regulation of smoothened signaling pathway
protein autophosphorylation
reticulophagy
fibroblast activation
cellular senescence
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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