Hamburger Menu Button
Thermo Fisher Scientific Logo
Sign in
Don't have an account ? Create Account
  • Products
    • Antibodies
    • Cell Culture Media
    • Chemicals
    • Chromatography Columns and Cartridges
    • Lab Equipment
    • Lab Plasticware and Supplies
    • Microplates
    • Oligos, Primers, Probes and Genes
    • TaqMan Real-Time PCR Assays
    • Greener Products
    • See all product categories
  • Applications
    • Bioprocessing
    • Cell Culture and Transfection
    • Cell and Gene Therapy
    • Chromatography
    • Molecular Testing
    • Digital Solutions
    • DNA and RNA Extraction and Analysis
    • Spectroscopy, Elemental and Isotope Analysis
    • See all applications and techniques
  • Services
    • 360° CDMO and CRO Solutions
    • CDMO Services
    • CRO Services
    • Custom Services
    • Financial and Leasing Services
    • Instrument Services
    • Lab Informatics
    • OEM and Commercial Supply
    • Training Services
    • Unity Lab Services
    • See all services
  • Help and Support
    • How to Order
    • Instrument Support
    • Learning Centers
    • Register for an Account
    • Technical Support Centers
    • See all help and support topics
  • Popular
    • TaqMan Real-Time PCR Assays
      TaqMan Real-Time PCR Assays
    • Antibodies
      Antibodies
    • Oligos, Primers & Probes
      Oligos, Primers & Probes
    • GeneArt Gene Synthesis
      GeneArt Gene Synthesis
    • Cell Culture Plastics
      Cell Culture Plastics
  • Who We Serve
    • Biotech
    • Biopharma
    • CDMO
    • Lab Diagnostics
    • Industrial and Applied Sciences
  • Promotions
  • Contact Us
  • Quick Order
  • Order Status and Tracking
  • Documents and Certificates
Thermo Fisher Scientific Logo

Search

Search All
Search button
          • Order Status
          • Quick Order
          • Promos
          • Sign in
            Sign in
            Don't have an account ? Create Account
            • Account
            • Check Order Status
            • Aspire Member Program
            • Connect: Lab, Data, Apps
            • Custom Products & Projects
            • Services Central
          • Primary Antibodies ›
          • CBP/p300 Antibodies

          Invitrogen

          Acetyl-CBP/p300 (Lys1499, Lys1535) Polyclonal Antibody

          1 Reference
          View all (2) CBP/p300 antibodies

          {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

          {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

          {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

          Datasheet
          Certificates
          Protocols
          Questions & Answers
          Datasheet
          Certificates
          Protocols
          Questions & Answers
          Datasheet
          Certificates
          Protocols
          Questions & Answers

          Cite Acetyl-CBP/p300 (Lys1499, Lys1535) Polyclonal Antibody

          Additional Information:
          {{banner.description}}
          {{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
          Acetyl-CBP/p300 (Lys1499, Lys1535) Polyclonal Antibody

          Product Details

          PA5-16185

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:1,000
          -

          Immunocytochemistry (ICC/IF)

          -
          View 1 publication 1 publication

          Immunoprecipitation (IP)

          1:50
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Non-human primate

          Published species

          Human

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Synthetic acetylated peptide corresponding to residues surrounding Lys1535 of human CBP
          3D Epitope / Immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          45 µg/mL

          Amount

          4.5 µg

          Purification

          Antigen affinity chromatography

          Storage buffer

          0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

          Contains

          no preservative

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_10979782

          Product Specific Information

          It is not recommended to aliquot this antibody.

          Target Information

          This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: CBP; CREBBP; CREB-binding protein; E1A binding protein p300; E1A-associated protein p300; E1A-binding protein, 300kD; Histone acetyltransferase p300; Histone butyryltransferase p300; Histone crotonyltransferase p300; Histone lysine acetyltransferase CREBBP; p300 HAT; Protein 2-hydroxyisobutyryltransferase p300; Protein isonicotinyltransferase p300; Protein lactyltransferas CREBBP; Protein lactyltransferas p300; Protein propionyltransferase p300; Protein-lysine acetyltransferase CREBBP; unnamed protein product

          View more View less

          Gene Aliases: A430090G16; A730011L11; AW558298; CBP; CBP/p300; CREBBP; EP300; KAT3A; KAT3B; MKHK1; MKHK2; P300; p300 HAT; p300/CBP; RSTS; RSTS1; RSTS2

          View more View less

          UniProt ID: (Human) Q92793, (Human) Q09472, (Mouse) B2RWS6

          View more View less

          Entrez Gene ID: (Human) 1387, (Mouse) 12914, (Human) 2033, (Mouse) 328572

          View more View less

          Function(s)
          transcription coactivator binding p53 binding chromatin binding damaged DNA binding transcription cofactor activity transcription coactivator activity transcription corepressor activity histone acetyltransferase activity protein binding zinc ion binding acetyltransferase activity transferase activity transferase activity, transferring acyl groups chromatin DNA binding MRF binding histone acetyltransferase activity (H3-K18 specific) histone acetyltransferase activity (H3-K27 specific) metal ion binding tau protein binding RNA polymerase II sequence-specific DNA binding transcription factor binding peptide-lysine-N-acetyltransferase activity peptide lactyltransferase (CoA-dependent) activity DNA-binding transcription factor binding RNA polymerase II regulatory region sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding transcriptional repressor activity, RNA polymerase II transcription factor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding transcription factor binding activating transcription factor binding peroxisome proliferator activated receptor binding SMAD binding transcription cofactor binding lysine N-acetyltransferase activity, acting on acetyl phosphate as donor beta-catenin binding H3 histone acetyltransferase activity H4 histone acetyltransferase activity ligand-dependent nuclear receptor binding histone H2B acetyltransferase activity androgen receptor binding NF-kappaB binding protein propionyltransferase activity pre-mRNA intronic binding STAT family protein binding peptide 2-hydroxyisobutyryltransferase activity histone lactyltransferase (CoA-dependent) activity acetylation-dependent protein binding peptide crotonyltransferase activity peptide butyryltransferase activity histone crotonyltransferase activity histone butyryltransferase activity histone reader activity histone H3K122 acetyltransferase activity RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding core promoter binding RNA polymerase II activating transcription factor binding core promoter proximal region DNA binding antigen binding protein C-terminus binding protein kinase binding protein complex binding nuclear hormone receptor binding glucocorticoid receptor binding bHLH transcription factor binding mitogen-activated protein kinase binding protein antigen binding histone modifying enzyme
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter double-strand break repair via homologous recombination response to hypoxia stimulatory C-type lectin receptor signaling pathway chromatin remodeling regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter protein acetylation signal transduction I-kappaB kinase/NF-kappaB signaling regulation of smoothened signaling pathway negative regulation of transcription from RNA polymerase I promoter N-terminal peptidyl-lysine acetylation positive regulation of transforming growth factor beta receptor signaling pathway protein destabilization cellular response to nutrient levels cellular response to UV homeostatic process embryonic digit morphogenesis positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter rhythmic process protein stabilization protein-containing complex assembly protein K48-linked deubiquitination energy homeostasis regulation of cellular response to heat positive regulation of protein localization to nucleus positive regulation of double-strand break repair via homologous recombination transcription, DNA-templated transcription from RNA polymerase II promoter cell proliferation histone acetylation germ-line stem cell population maintenance positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of G1/S transition of mitotic cell cycle autophagosome assembly somitogenesis thigmotaxis behavioral defense response gluconeogenesis glycolytic process regulation of glycolytic process internal protein amino acid acetylation apoptotic process JAK-STAT cascade nervous system development heart development skeletal muscle tissue development learning or memory circadian rhythm lipid biosynthetic process organ morphogenesis regulation of autophagy negative regulation of autophagy positive regulation of gene expression regulation of mitochondrion organization positive regulation of neuron projection development internal peptidyl-lysine acetylation B cell differentiation platelet formation lung development negative regulation of protein complex assembly negative regulation of protein oligomerization multicellular organism growth megakaryocyte development endodermal cell differentiation swimming TORC1 signaling TORC2 signaling positive regulation of protein import into nucleus intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator protein kinase B signaling response to estrogen positive regulation by host of viral transcription fat cell differentiation negative regulation of gluconeogenesis positive regulation of gene expression, epigenetic positive regulation of JAK-STAT cascade positive regulation of protein kinase B signaling canonical Wnt signaling pathway face morphogenesis regulation of androgen receptor signaling pathway peptidyl-lysine propionylation protein localization to chromatin cellular response to leucine tricarboxylic acid metabolic process T-helper 17 cell lineage commitment regulation of tubulin deacetylation peptidyl-lysine crotonylation peptidyl-lysine butyrylation regulation of signal transduction by p53 class mediator positive regulation of TORC1 signaling positive regulation of TORC2 signaling positive regulation of T-helper 17 cell lineage commitment positive regulation of protein phosphorylation positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response cell cycle response to glucose positive regulation of glycoprotein biosynthetic process positive regulation of cell death positive regulation of muscle atrophy cell differentiation positive regulation of cell growth negative regulation of cellular metabolic process positive regulation of cellular metabolic process positive regulation of protein binding positive regulation of collagen biosynthetic process positive regulation of protein import into nucleus, translocation positive regulation of histone acetylation response to drug negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of DNA binding histone H3 acetylation histone H4 acetylation histone H2B acetylation positive regulation of translation positive regulation of axon extension positive regulation of cell size positive regulation of proteolysis positive regulation of protein secretion cartilage development response to calcium ion regulation of angiotensin metabolic process positive regulation of sarcomere organization negative regulation of cell death protein-DNA complex assembly response to dexamethasone positive regulation of protein acetylation regulation of nucleic acid-templated transcription negative regulation of miRNA metabolic process
          It has to be done as per old AB suggested Products section.

          Disclaimer

          Close

          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          guarantee_icon

          Performance Guarantee

          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

          Learn more
          help_icon

          We're here to help

          Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

          Contact tech support
          Ordering Plus Icon Minus Icon
          • Order Status
          • Order Help
          • Quick Order
          • Supply Center
          • eProcurement
          Support Plus Icon Minus Icon
          • Help and Support
          • Contact Us
          • Technical Support Centers
          • Documents and Certificates
          • Report a Site Issue
          Resources Plus Icon Minus Icon
          • Learning Centers
          • Promotions
          • Events and Webinars
          • Social Media
          About Thermo Fisher Plus Icon Minus Icon
          • About Us About Us
          • Careers Careers
          • Investors Investors
          • News News
          • Social Responsibility Social Responsibility
          • Trademarks
          • Consumer Health Data Privacy Policy Consumer Health Data Privacy Policy
          • Policies and Notices
          Our Portfolio Plus Icon Minus Icon
          • Thermo Scientific
          • Applied Biosystems
          • Invitrogen
          • Gibco
          • Ion Torrent
          • Fisher Scientific
          • Unity Lab Services
          • Patheon
          • PPD
          • Terms & Conditions
          • Privacy Notice
          • Price & Freight Policy
          © 2006-2026 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified.
          United States flag icon
          United States

          Your items have has been added!


          Host server : magellan-search-green-794c4b9cd6-8pzg4:80/100.66.75.138:80.
          git-commit: 7e8dd63fde7d4486b98ef9ac5cf4e365aa842ffe
          git-url: https://github.com/thermofisher/magellan-search
          git-branch: release/2.52.0-Offline