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          • Primary Antibodies ›
          • ENPP1 Antibodies

          Invitrogen

          ENPP1 Polyclonal Antibody

          3 Published Figures
          3 References
          View all (12) ENPP1 antibodies

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          Cite ENPP1 Polyclonal Antibody

          Additional Information:
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          • Antibody Testing Data (1)
          • Published Figures (3)
          ENPP1 Antibody in Western Blot (WB)
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          ENPP1 Antibody in Western Blot (WB)
          Group 53 Created with Sketch.

          FIGURE: 1 / 4

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          ENPP1 Antibody (PA5-17097) in WB

          Western blot analysis of ENPP1 in extracts from rat KNRK and human HepG2 cells using ENPP1 polyclonal antibody (Product # PA5-17097). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          View Product

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          ENPP1 Antibody in Western Blot (WB)
          ENPP1 Antibody in Western Blot (WB)
          ENPP1 Antibody in Western Blot (WB)
          ENPP1 Antibody in Western Blot (WB)

          Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

          ENPP1 Polyclonal Antibody

          Product Details

          PA5-17097

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:1,000
          View 3 publications 3 publications

          Immunoprecipitation (IP)

          1:50
          -
          Product Specifications

          Species Reactivity

          Human, Rat

          Published species

          Mouse

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Synthetic peptide corresponding to residues surrounding Leu520 of human ENPP1
          3D Epitope / Immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          162 µg/mL

          Amount

          16.2 µg

          Purification

          Antigen affinity chromatography

          Storage buffer

          0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

          Contains

          no preservative

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_10979019

          Product Specific Information

          It is not recommended to aliquot this antibody.

          Target Information

          This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: alkaline phosphodiesterase 1; alkaline phosphodiesterase I; E-NPP 1; HGNC:3356; Ly-41 antigen; membrane component, chromosome 6, surface marker 1; NPPase; nucleotide diphosphatase; nucleotide pyrophosphatase; OTTHUMP00000043194; phosphodiesterase I/nucleotide pyrophosphatase 1; plasma cell membrane glycoprotein PC-1; plasma-cell membrane glycoprotein 1; plasma-cell membrane glycoprotein PC-1; unnamed protein product

          View more View less

          Gene Aliases: ARHR2; COLED; M6S1; NPP1; NPPS; PC-1; Pc1; PCA1; PDNP1

          View more View less

          UniProt ID: (Human) P22413, (Rat) Q924C3

          View more View less

          Entrez Gene ID: (Human) 5167, (Rat) 85496

          View more View less

          Function(s)
          nucleic acid binding 3',5'-cyclic-AMP phosphodiesterase activity exonuclease activity phosphodiesterase I activity nucleotide diphosphatase activity scavenger receptor activity insulin receptor binding calcium ion binding protein binding ATP binding zinc ion binding hydrolase activity phosphatase activity polysaccharide binding GTP diphosphatase activity UTP diphosphatase activity protein homodimerization activity metal ion binding nucleoside-triphosphate diphosphatase activity ATP diphosphatase activity 3'-phosphoadenosine 5'-phosphosulfate binding cyclic-GMP-AMP hydrolase activity phosphoric diester hydrolase activity pyrophosphatase activity identical protein binding
          Process(es)
          generation of precursor metabolites and energy phosphate-containing compound metabolic process immune response nucleoside triphosphate catabolic process gene expression vesicle-mediated transport bone mineralization negative regulation of cell growth melanocyte differentiation regulation of bone mineralization negative regulation of bone mineralization inorganic diphosphate transport cellular phosphate ion homeostasis cellular response to insulin stimulus response to ATP negative regulation of fat cell differentiation negative regulation of glycogen biosynthetic process ATP metabolic process negative regulation of glucose import negative regulation of insulin receptor signaling pathway animal organ development 3'-phosphoadenosine 5'-phosphosulfate metabolic process phosphate ion homeostasis nucleic acid metabolic process ossification vasculogenesis osteoblast differentiation kidney development liver development B-1 B cell homeostasis endochondral ossification morphogenesis of an epithelium response to dietary excess plasma cell differentiation inflammatory response to antigenic stimulus glycolytic process fatty acid metabolic process mitochondrion organization smoothened signaling pathway heart development sensory perception of sound adult walking behavior cell proliferation determination of adult lifespan adult locomotory behavior fibroblast growth factor receptor signaling pathway response to wounding response to mechanical stimulus magnesium ion homeostasis microglia differentiation Wnt signaling pathway organic phosphonate metabolic process spinal cord development cerebellum development striatum development hippocampus development olfactory bulb development cerebral cortex development central nervous system myelination T cell differentiation macrophage differentiation negative regulation of ossification osteoclast differentiation axon regeneration biomineral tissue development response to magnesium ion response to insulin tooth mineralization response to vitamin B6 post-embryonic forelimb morphogenesis multicellular organism growth bone mineralization involved in bone maturation aorta development ligamentous ossification response to platelet-derived growth factor collagen-activated signaling pathway hormone metabolic process middle ear morphogenesis odontogenesis glucose homeostasis mRNA transcription from RNA polymerase II promoter defense response to protozoan skin development fat cell differentiation bone resorption bone remodeling sensory perception of temperature stimulus sensory perception of mechanical stimulus cartilage development neuron apoptotic process calcium ion homeostasis long-term synaptic potentiation bone trabecula formation bone development endochondral bone morphogenesis adipose tissue development fat pad development artery development articular cartilage development protein poly-ADP-ribosylation mucus secretion vitamin D3 metabolic process cellular response to mechanical stimulus cellular response to cAMP diphosphate metabolic process cellular response to acidic pH cementum mineralization cellular response to transforming growth factor beta stimulus hematopoietic stem cell migration to bone marrow oligodendrocyte apoptotic process glucose import across plasma membrane bone growth response to Gram-positive bacterium inhibition of non-skeletal tissue mineralization microglial cell migration response to sodium phosphate cellular response to sodium phosphate vascular associated smooth muscle cell migration vascular associated smooth muscle cell proliferation
          It has to be done as per old AB suggested Products section.

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