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Invitrogen
Caspr2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-17166
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sourrounding Glu1320 of human Caspr2
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cell recognition molecule Caspr2; contactin associated protein like 2; contactin associated protein-like 2; DKFZp781D1846; homolog of Drosophila neurexin IV; mKIAA0868 protein-like; unnamed protein product
Gene Aliases: 5430425M22Rik; AUTS15; CASPR2; CDFE; mKIAA0868; NRXN4; PTHSL1
UniProt ID: (Human) Q9UHC6, (Mouse) Q9CPW0
Entrez Gene ID: (Human) 26047, (Mouse) 66797, (Rat) 500105
startle response
signal transduction
nervous system development
central nervous system development
brain development
learning
neuron recognition
cell proliferation
transmission of nerve impulse
striatum development
limbic system development
thalamus development
cerebral cortex development
adult behavior
neuron projection development
social behavior
vocal learning
clustering of voltage-gated potassium channels
neuron projection morphogenesis
prepulse inhibition
superior temporal gyrus development
protein localization to juxtaparanode region of axon
vocalization behavior
positive regulation of gap junction assembly
cell morphogenesis
in utero embryonic development
response to dietary excess
inflammatory response
mitochondrion organization
cell adhesion
chemical synaptic transmission
axonogenesis
rhythmic behavior
grooming behavior
locomotory behavior
protein localization
associative learning
response to heat
response to xenobiotic stimulus
response to mechanical stimulus
response to light intensity
response to hormone
gene expression
glial cell proliferation
neuronal action potential
cerebellum development
cerebellar Purkinje cell layer morphogenesis
central nervous system myelination
neuron differentiation
TOR signaling
regulation of synaptic transmission, GABAergic
negative regulation of synaptic transmission, GABAergic
cell junction assembly
cell junction maintenance
multicellular organism growth
intracellular signal transduction
myelination
circadian sleep/wake cycle
fat cell differentiation
locomotor rhythm
response to pain
behavioral response to pain
neuromuscular process controlling posture
neuromuscular process
negative regulation of protein kinase B signaling
excitatory postsynaptic potential
dendritic spine development
neural precursor cell proliferation
motor behavior
ERK1 and ERK2 cascade
walking behavior
dendritic spine organization
dendritic spine maintenance
postsynaptic density organization
response to interleukin-17
neuromuscular junction development, skeletal muscle fiber
excitatory chemical synaptic transmission
inhibitory chemical synaptic transmission
regulation of postsynaptic membrane neurotransmitter receptor levels
maintenance of synapse structure
action potential initiation
dendrite arborization
response to metformin
negative regulation of neuronal action potential
positive regulation of neuronal action potential
excitatory synapse assembly
inhibitory synapse assembly
glutamatergic neuron differentiation
embryonic brain development
response to odorant
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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