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Invitrogen

GluR2/GluR3/GluR4 Polyclonal Antibody

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GluR2/GluR3/GluR4 Polyclonal Antibody

Product Details

PA5-17314

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues surrounding Ser720 of human GluR2
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

79 µg/mL

Amount

7.9 µg

Purification

Antigen affinity chromatography, Protein A

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10985891

Product Specific Information

It is not recommended to aliquot this antibody.

Target Information

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (Q/R and R/G), which is thought to render the channels impermeable to Ca(2+), and to affect the kinetic aspects of these channels in rat brain. Alternative splicing, resulting in transcript variants encoding different isoforms (flip and flop), has been noted for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: AMPA receptor subunit GluA2; AMPA receptor subunit GluA3; AMPA selective glutamate receptor; AMPA-selective glutamate receptor 2; AMPA-selective glutamate receptor 3; AMPA-selective glutamate receptor 4; dJ1171F9.1; gluR-3; gluR-4; gluR-D; GluR2; glutamate receptor; glutamate receptor (GluR-B); glutamate receptor (GluR-C); glutamate receptor (GluR-D); glutamate receptor B; glutamate receptor C; glutamate receptor channel alpha 4; glutamate receptor channel alpha3 subunit; glutamate receptor ionotropic, AMPA 2; glutamate receptor ionotropic, AMPA 4; glutamate receptor subunit 3; glutamate receptor, ionotrophic, AMPA 3; glutamate receptor, ionotrophic, AMPA 4; glutamate receptor, ionotropic, AMPA 2; glutamate receptor, ionotropic, AMPA 3; glutamate receptor, ionotropic, AMPA 4; glutamate receptor, ionotropic, AMPA3 (alpha 3); glutamate receptor, ionotropic, AMPA4 (alpha 4); spike wave 1; unnamed protein product

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Gene Aliases: 2900064I19Rik; GluA2; GluA3; GluA4; GluA4-ATD; Glur-2; GluR-3; Glur-4; GluR-B; GLUR-C; GluR-D; GluR-K2; GLUR-K3; GLUR2; GLUR3; GLUR4; GLUR4C; Gluralpha3; Gluralpha4; GLURB; GLURC; GLURD; HBGR2; iGluR3; MRX94; MRXSW; NEDLIB; NEDSGA; spkw1

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UniProt ID: (Human) P42262, (Human) P42263, (Human) P48058, (Rat) P19491, (Mouse) Q9Z2W9, (Rat) P19492, (Mouse) Q9Z2W8, (Rat) P19493

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Entrez Gene ID: (Human) 2891, (Human) 2892, (Human) 2893, (Rat) 29627, (Mouse) 14800, (Mouse) 53623, (Rat) 29628, (Mouse) 14802, (Rat) 29629

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Function(s)
beta-amyloid binding ionotropic glutamate receptor activity AMPA glutamate receptor activity ion channel activity protein binding ligand-gated ion channel activity signaling receptor activity ligand-gated monoatomic cation channel activity transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential glutamate-gated calcium ion channel activity ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential SNARE binding extracellular ligand-gated ion channel activity extracellular-glutamate-gated ion channel activity cytoskeletal protein binding kainate selective glutamate receptor activity immunoglobulin binding protein kinase binding PDZ domain binding glutamate receptor binding ionotropic glutamate receptor binding identical protein binding macromolecular complex binding scaffold protein binding ligand-gated calcium channel activity
Process(es)
ion transport chemical synaptic transmission ion transmembrane transport negative regulation of smooth muscle cell apoptotic process ionotropic glutamate receptor signaling pathway synaptic transmission, glutamatergic modulation of synaptic transmission positive regulation of synaptic transmission, glutamatergic regulation of postsynaptic membrane potential regulation of presynaptic membrane potential glutamate receptor signaling pathway calcium-mediated signaling protein homotetramerization protein heterotetramerization long-term synaptic potentiation regulation of receptor recycling response to lithium ion cerebral cortex development receptor internalization establishment of protein localization positive regulation of synaptic transmission protein tetramerization regulation of synaptic plasticity by chemical substance regulation of synaptic transmission, glutamatergic excitatory postsynaptic potential response to fungicide cellular response to amine stimulus AMPA glutamate receptor clustering cation transmembrane transport regulation of long term synaptic depression response to phorbol 13-acetate 12-myristate cellular response to glycine cellular response to brain-derived neurotrophic factor stimulus conditioned place preference positive regulation of excitatory postsynaptic potential regulation of synapse structure or activity
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