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Invitrogen
NOD1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-17328
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues near the carboxy terminus of Nod1 protein
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
172 µg/mL
Amount
17.2 µg
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
NOD1 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD1 contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and ten tandem leucine-rich repeats (LRRs) in its C-terminus. The CARD is involved in apoptotic signaling, and NOD1 activates caspase-9 and NF-kappa-B. LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Apaf-1/Ced-4 family member; caspase recruitment domain 4; caspase recruitment domain family, member 4; caspase recruitment domain-containing protein 4; CED-4/APAF-1 cell death family member; NLR family, CARD domain containing 1; NOD1; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 1; unnamed protein product
Gene Aliases: C230079P11; CARD4; CLR7.1; F830007N14Rik; hNod1; mNod1; NLRC1; RGD1562269
UniProt ID: (Human) Q9Y239, (Mouse) Q8BHB0
Entrez Gene ID: (Human) 10392, (Rat) 500133, (Mouse) 107607
positive regulation of cytokine production
pattern recognition receptor signaling pathway
positive regulation of dendritic cell antigen processing and presentation
positive regulation of autophagy
detection of bacterium
positive regulation of interleukin-1 beta production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
positive regulation of tumor necrosis factor production
positive regulation of stress-activated MAPK cascade
response to endoplasmic reticulum stress
intracellular signal transduction
defense response to bacterium
regulation of apoptotic process
positive regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of JNK cascade
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
positive regulation of nitric-oxide synthase activity
positive regulation of ERK1 and ERK2 cascade
nucleotide-binding oligomerization domain containing 1 signaling pathway
cellular response to muramyl dipeptide
positive regulation of NIK/NF-kappaB signaling
positive regulation of xenophagy
defense response
apoptotic process
inflammatory response
signal transduction
detection of biotic stimulus
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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