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Invitrogen

Phospho-PDGFRB (Tyr751) Polyclonal Antibody

View all (97) PDGFRB (CD140b) antibodies

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Phospho-PDGFRB (Tyr751) Polyclonal Antibody

Product Details

PA5-17753

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Flow Cytometry (Flow)

1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic phosphopeptide corresponding to residues surrounding pTyr751 of human PDGF receptor β
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

14 µg/mL

Amount

1.4 µg

Purification

Antigen affinity chromatography

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10986102

Product Specific Information

It is not recommended to aliquot this antibody.

Target Information

PDGFRB is a receptor tyrosine kinase and has been implicated in atherogenesis and in cell transformation by the SIS oncogene. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. The gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses PDGFRB (CD140b) to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Activated tyrosine kinase PDGFRB; beta platelet-derived growth factor receptor; beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; CD140b antigen; PDGF beta chain; PDGF Receptor beta; PDGF-R-beta; PDGFR-beta; platelet derived growth factor receptor, beta polypeptide; platelet-derived growth factor receptor 1; Platelet-derived growth factor receptor, beta; platelet-derived growth factor receptor, beta polypeptide; unnamed protein product; V1-Pdgfrb

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Gene Aliases: CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD; PDGFR; PDGFR-1; PDGFR1; PENTT

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UniProt ID: (Human) P09619, (Rat) Q05030, (Mouse) P05622

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Entrez Gene ID: (Human) 5159, (Rat) 24629, (Mouse) 18596

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Function(s)
protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity platelet activating factor receptor activity platelet-derived growth factor-activated receptor activity platelet-derived growth factor beta-receptor activity GTPase activator activity receptor binding platelet-derived growth factor receptor binding protein binding ATP binding kinase activity enzyme binding protein kinase binding vascular endothelial growth factor binding platelet-derived growth factor binding phospholipase C activator activity phosphatidylinositol 3-kinase binding
Process(es)
angiogenesis blood vessel development in utero embryonic development kidney development tissue homeostasis glycosaminoglycan biosynthetic process signal transduction transmembrane receptor protein tyrosine kinase signaling pathway sensory organ development positive regulation of cell proliferation male gonad development response to toxic substance positive regulation of smooth muscle cell migration cell migration peptidyl-tyrosine phosphorylation hemopoiesis adrenal gland development positive regulation of cell migration response to estradiol response to retinoic acid regulation of actin cytoskeleton organization positive regulation of collagen biosynthetic process response to lipid response to fluid shear stress positive regulation of Rho protein signal transduction cell migration involved in vasculogenesis intracellular signal transduction metanephric mesenchymal cell migration platelet-derived growth factor receptor-beta signaling pathway positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway aorta morphogenesis cellular response to platelet-derived growth factor stimulus positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway response to hydrogen peroxide positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of MAP kinase activity response to estrogen positive regulation of mitotic nuclear division protein autophosphorylation platelet-derived growth factor receptor signaling pathway positive regulation of fibroblast proliferation embryonic organ development positive regulation of smooth muscle cell proliferation skeletal system morphogenesis smooth muscle tissue development inner ear development regulation of peptidyl-tyrosine phosphorylation positive regulation of calcium-mediated signaling positive regulation of chemotaxis positive regulation of multicellular organismal process positive regulation of protein kinase B signaling cardiac myofibril assembly response to hyperoxia cell chemotaxis lung growth cell migration involved in coronary angiogenesis retina vasculature development in camera-type eye cellular response to hydrogen peroxide positive regulation of ERK1 and ERK2 cascade smooth muscle cell chemotaxis metanephric mesenchyme development metanephric glomerular mesangium development metanephric glomerular mesangial cell proliferation involved in metanephros development metanephric glomerulus morphogenesis metanephric glomerular capillary formation metanephric comma-shaped body morphogenesis metanephric S-shaped body morphogenesis positive regulation of calcium ion import ruffle assembly response to ceramide positive regulation of intracellular signal transduction positive regulation of reactive oxygen species metabolic process positive regulation of hepatic stellate cell activation positive regulation of DNA biosynthetic process cardiac vascular smooth muscle cell differentiation G-protein coupled receptor signaling pathway smooth muscle adaptation positive regulation of MAPK cascade
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