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Invitrogen
VASP Polyclonal Antibody
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FIGURE: 1 / 2
VASP Antibody (PA5-17769) in WB
Western blot was performed using VASP Polyclonal Antibody (Product # PA5-17769) and a 50 kDa band corresponding to VASP was observed in HEL92.1.7, A431, HeLa, Mouse Spleen and Mouse Lung along with an uncharacterized band (*) at ~40 kDa; and was absent in HEK293, SHSY5Y, Mouse Brain, Mouse Cerebellum, Mouse Skeletal Muscle and Mouse Kidney. Whole cell extracts (30 µg lysate) of HEL 92.1.7 (Lane 1), A431 (Lane 2), HEK-293 (Lane 3), HeLa (Lane 4), SHSY5Y (Lane 5), tissue extracts (30 µg lysate) of Mouse Spleen (Lane 6), Mouse Lung (Lane 7), ... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-17769
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues surrounding Ser157 of human VASP
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
This antibody is not cross-reactive with VASP homologues, such as EVL and Mena.
Target Information
Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Enah/Vasp-like; proline-rich cytoskeletal protein; unnamed protein product
UniProt ID: (Human) P50552, (Mouse) P70460
Entrez Gene ID: (Human) 7408, (Mouse) 22323, (Rat) 361517
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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