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Invitrogen
Lamin A (Cleaved Asp230) Polyclonal Antibody
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FIGURE: 1 / 3
Lamin A (Cleaved Asp230) Antibody (PA5-17838) in ICC/IF
Immunofluorescent analysis of Cleaved Lamin A in HeLa cells, staurosporine-treated, using a Cleaved Lamin A polyclonal antibody (Product # PA5-17838) (green). Actin filaments are labeled with a fluorescent red phalloidin. DNA is labeled using a fluorescent blue dye.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-17838
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino-terminal residues surrounding Asp230 in human lamin A
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
This antibody is not cross-reactive with full length lamin A or lamin C.
Target Information
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 70 kDa lamin; epididymis secretory sperm binding protein; lamin A; lamin A protein; lamin A/C; lamin A/C-like 1; lamin C; lamin C protein; lamin C2; lamin-A/C; mandibuloacral dysplasia type A; nuclear envelope protein; OTTHUMP00000015843; OTTHUMP00000015846; OTTHUMP00000015847; prelamin-A/C; progerin; renal carcinoma antigen NY-REN-32; unnamed protein product
Gene Aliases: CDCD1; CDDC; CMD1A; CMT2B1; Dhe; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC; LMNL1; MADA; PRO1
UniProt ID: (Human) P02545, (Mouse) P48678
Entrez Gene ID: (Human) 4000, (Mouse) 16905, (Rat) 60374
double-strand break repair via nonhomologous end joining
protein import into nucleus
nucleus organization
nuclear envelope organization
nuclear migration
muscle organ development
protein localization
negative regulation of cell proliferation
positive regulation of gene expression
establishment of cell polarity
regulation of cell migration
establishment or maintenance of microtubule cytoskeleton polarity
heterochromatin assembly
regulation of protein stability
regulation of telomere maintenance
protein localization to nucleus
positive regulation of osteoblast differentiation
nuclear pore localization
ventricular cardiac muscle cell development
cellular response to hypoxia
negative regulation of mesenchymal cell proliferation
negative regulation of release of cytochrome c from mitochondria
cellular senescence
protein localization to nuclear envelope
regulation of protein localization to nucleus
negative regulation of cardiac muscle hypertrophy in response to stress
negative regulation of adipose tissue development
DNA double-strand break attachment to nuclear envelope
negative regulation of extrinsic apoptotic signaling pathway
spermatogenesis
response to mechanical stimulus
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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