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Invitrogen

Phospho-EGFR/ErbB2 (Tyr1173, Tyr1248) Polyclonal Antibody

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Phospho-EGFR/ErbB2 (Tyr1173, Tyr1248) Polyclonal Antibody

Product Details

PA5-17844

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic phosphopeptide corresponding to residues surrounding pTyr1248 of human ErbB2
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

Antigen affinity chromatography

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11001612

Product Specific Information

It is not recommended to aliquot this antibody.

Target Information

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: approximately 68 kDa secreted autoinhibitor glycoprotein; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; c-erb B2/neu protein; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; contains extracellular domain; epidermal growth factor receptor tyrosine kinase domain; erb-b2 receptor tyrosine kinase 1; GIG40; HER2 receptor; HER2/neu receptor; herstatin; human epidermal growth factor receptor 2; membrane protein; metastatic lymph node gene 19 protein; neuro/glioblastoma derived oncogene homolog; neuroblastoma/glioblastoma derived oncogene homolog; Oncogene ERBB; PIG61; proto-oncogene c-ErbB-1; proto-oncogene c-ErbB-2; proto-oncogene Neu; receptor tyrosine-protein kinase erbB-1; tyrosine kinase-type cell surface receptor HER2; unnamed protein product; Urogastrone; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog; wa2; Wa5

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Gene Aliases: c-ERB-2; c-ERB2; CD340; ERBB; ERBB1; ERRP; HER-2; HER-2/neu; HER1; HER2; mENA; MLN 19; MLN-19; NEU; NGL; NISBD2; NNCIS; p185(erbB2); PIG61; TKR1; VSCN2

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UniProt ID: (Human) P00533, (Human) P04626

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Entrez Gene ID: (Human) 1956, (Human) 2064

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Function(s)
chromatin binding double-stranded DNA binding protein kinase activity MAP kinase kinase kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane signaling receptor activity epidermal growth factor-activated receptor activity protein binding ATP binding kinase activity enzyme binding kinase binding protein phosphatase binding protein tyrosine kinase activator activity ubiquitin protein ligase binding identical protein binding cadherin binding epidermal growth factor binding actin filament binding ATPase binding RNA polymerase I core binding receptor binding coreceptor activity growth factor binding receptor tyrosine kinase binding ErbB-3 class receptor binding protein heterodimerization activity
Process(es)
protein phosphorylation signal transduction cell surface receptor signaling pathway enzyme linked receptor protein signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway epidermal growth factor receptor signaling pathway cell proliferation Schwann cell development peptidyl-tyrosine phosphorylation neuron differentiation positive regulation of cell growth regulation of microtubule-based process positive regulation of Rho protein signal transduction intracellular signal transduction ERBB signaling pathway ERBB2 signaling pathway ERBB2-ERBB3 signaling pathway ERBB2-EGFR signaling pathway ERBB2-ERBB4 signaling pathway wound healing regulation of cell proliferation negative regulation of apoptotic process positive regulation of MAP kinase activity positive regulation of MAPK cascade protein kinase B signaling positive regulation of translation regulation of angiogenesis positive regulation of cell adhesion positive regulation of transcription from RNA polymerase I promoter positive regulation of JNK cascade positive regulation of epithelial cell proliferation regulation of ERK1 and ERK2 cascade cellular response to growth factor stimulus cellular response to epidermal growth factor stimulus semaphorin-plexin signaling pathway positive regulation of protein targeting to membrane neurotransmitter receptor localization to postsynaptic specialization membrane MAPK cascade ossification positive regulation of protein phosphorylation learning or memory positive regulation of cell proliferation negative regulation of macroautophagy positive regulation of cell migration positive regulation of peptidyl-serine phosphorylation positive regulation of toll-like receptor 9 signaling pathway negative regulation of epidermal growth factor receptor signaling pathway negative regulation of protein catabolic process positive regulation of phosphorylation positive regulation of DNA repair positive regulation of DNA replication positive regulation of transcription from RNA polymerase II promoter positive regulation of fibroblast proliferation regulation of peptidyl-tyrosine phosphorylation protein insertion into membrane positive regulation of protein kinase B signaling response to UV-A positive regulation of ERK1 and ERK2 cascade cellular response to amino acid stimulus cellular response to estradiol stimulus positive regulation of protein kinase C signaling positive regulation of canonical Wnt signaling pathway cell-cell adhesion positive regulation of cGAS/STING signaling pathway positive regulation of G1/S transition of mitotic cell cycle positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of protein localization to plasma membrane negative regulation of cardiocyte differentiation
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