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Invitrogen

Phospho-MEK3/MEK6 (Ser189, Ser207) Polyclonal Antibody

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Phospho-MEK3/MEK6 (Ser189, Ser207) Polyclonal Antibody

Product Details

PA5-17887

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic phosphopeptide corresponding to residues around pSer189/207 of human MKK3
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

40 µg/mL

Amount

4 µg

Purification

Antigen affinity chromatography

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10980081

Product Specific Information

It is not recommended to aliquot this antibody.

Target Information

This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases, act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Colorectal Cancer Metastasis-Suppressed LncRNA; dual specificity mitogen-activated protein kinase kinase 3-like; MAP kinase kinase 3; MAP kinase kinase 6; MAP2K3; MAPK/ERK kinase 3; MAPK/ERK kinase 6; MAPKK 3; MAPKK 6; MEK 3; MEK 6; OTTHUMP00000166044; p38 specific mitogen-activated protein kinase; protein kinase, mitogen activated, kinase 6; protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6); SAPK kinase 2; SAPK kinase 3; stress-activated protein kinase kinase 2; stress-activated protein kinase kinase 3; unnamed protein product

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Gene Aliases: CRCMSL; MAPKK 3; MAPKK 6; MAPKK3; MAPKK6; MEK3; MEK6; MKK3; MKK3b; MKK6; PRKMK3; PRKMK6; SAPKK-2; SAPKK-3; SAPKK2; SAPKK3

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UniProt ID: (Human) P46734, (Human) P52564, (Mouse) O09110, (Mouse) P70236

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Entrez Gene ID: (Human) 5606, (Human) 5608, (Rat) 303200, (Mouse) 26397, (Rat) 114495, (Mouse) 26399

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Function(s)
protein kinase activity MAP kinase kinase activity protein tyrosine kinase activity protein binding ATP binding protein kinase binding protein serine kinase activity protein serine/threonine kinase activity identical protein binding nucleotide binding
Process(es)
MAPK cascade osteoblast differentiation signal transduction stress-activated protein kinase signaling cascade nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway p38MAPK cascade signal transduction in response to DNA damage stress-activated MAPK cascade regulation of cell cycle bone development cellular senescence negative regulation of cold-induced thermogenesis regulation of signal transduction by p53 class mediator regulation of intracellular signal transduction positive regulation of protein phosphorylation response to ischemia protein phosphorylation response to xenobiotic stimulus ovulation cycle process positive regulation of prostaglandin secretion positive regulation of apoptotic process positive regulation of MAP kinase activity positive regulation of MAPK cascade cardiac muscle contraction cellular response to sorbitol regulation of cytokine production inflammatory response heart development negative regulation of hippo signaling cellular response to vascular endothelial growth factor stimulus positive regulation of blood vessel endothelial cell migration positive regulation of protein kinase activity positive regulation of transcription, DNA-templated cellular response to lipopolysaccharide protein maturation pyroptosis cellular response to UV-B NLRP1 inflammasome complex assembly
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