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Invitrogen
ZBED3 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-20767
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 17 amino acid peptide from near the amino terminus of human ZBED3.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Despite its predicted molecular weight, ZBED3 often migrates at a higher molecular weight in SDS-PAGE. A suggested positive control is A-20 cell lysate.
PA5-20767 can be used with blocking peptide PEP-0881.
Target Information
Axin is a key modulator of the Wnt/beta-catenin pathway and acts as a scaffold protein in phosphorylating and degrading cytoplasmic beta-catenin. ZBED3, a member of the Zinc finger BED-type domain containing superfamily, has been recently identified as an Axin-interacting protein and has been suggested to modulate the Wnt/beta-catenin signaling pathway. RNA interference (RNAi) experiments targeting ZBED3 RNA attenuated Wnt-induced beta-catenin accumulation, lymphoid enhancer binding factor-1-dependent luciferase reporter activity, and Wnt gene expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 2610005H11Rik; axin-interacting protein; unnamed protein product; zinc finger, BED domain containing 3
Gene Aliases: 0610037K01Rik; 2610005H11Rik
UniProt ID: (Human) Q96IU2, (Mouse) Q9D0L1
Entrez Gene ID: (Human) 84327, (Mouse) 72114, (Rat) 361881
negative regulation of protein phosphorylation
actin filament organization
response to glucose
response to insulin
positive regulation of embryonic development
positive regulation of transcription from RNA polymerase II promoter
protein stabilization
establishment of spindle localization
endoplasmic reticulum localization
mitochondrion localization
positive regulation of canonical Wnt signaling pathway
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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