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Invitrogen
RNF8 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-20961
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 14 amino acid peptide near the carboxy terminus of human RNF8.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is human lung tissue lysate.
PA5-20961 can be used with blocking peptide PEP-1075.
Target Information
The protein encoded by this gene contains a RING finger motif and a FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ActA binding protein 2; actA-interacting protein 37; C3HC4-type zinc finger protein; FLJ12013; OTTHUMP00000039684; ring finger protein (C3HC4 type) 8; ring finger protein 8, E3 ubiquitin protein ligase; RING-type E3 ubiquitin transferase RNF8; Rnf8; UBC13/UEV-interacting ring finger protein; unnamed protein product; UURF1
Gene Aliases: 3830404E21Rik; AIP37; hRNF8; laXp180
UniProt ID: (Human) O76064, (Mouse) Q8VC56, (Rat) Q4KLN8
Entrez Gene ID: (Human) 9025, (Mouse) 58230, (Rat) 361815
double-strand break repair
double-strand break repair via nonhomologous end joining
chromatin organization
ubiquitin-dependent protein catabolic process
cellular response to DNA damage stimulus
response to ionizing radiation
protein ubiquitination
negative regulation of transcription elongation from RNA polymerase II promoter
sperm chromatin condensation
regulation of gene expression, epigenetic
signal transduction in response to DNA damage
isotype switching
positive regulation of DNA repair
protein autoubiquitination
protein K63-linked ubiquitination
protein K48-linked ubiquitination
protein K6-linked ubiquitination
DNA repair-dependent chromatin remodeling
positive regulation of double-strand break repair via homologous recombination
protein localization to site of double-strand break
biological_process
interstrand cross-link repair
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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