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Invitrogen
Fibrinogen gamma Polyclonal Antibody
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FIGURE: 1 / 6
Fibrinogen gamma Antibody (PA5-21968) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of Fibrinogen gamma was performed in HeLa cells fixed in 4% paraformaldehyde at RT for 15 min. Green: Fibrinogen gamma Polyclonal Antibody (Product # PA5 21968) diluted at 1:500. Red: alpha Tubulin, a cytoskeleton marker. Blue: Hoechst 33342 staining.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-21968
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human Fibrinogen gamma. The exact sequence is proprietary.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.77 mg/mL
Amount
177 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol, 1% BSA
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: HepG2, human plasma, HepG2 sup., mouse plasma, rat plasma.
Predicted reactivity: Mouse (85%), Rat (85%), Pig (84%), Bovine (82%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FGG; fibg; fibrinogen, gamma polypeptide; gamma'; testicular tissue protein Li 70; unnamed protein product
Gene Aliases: 3010002H13Rik
UniProt ID: (Bovine) P12799, (Human) P02679, (Rat) P02680, (Mouse) Q8VCM7
Entrez Gene ID: (Bovine) 280792, (Human) 2266, (Rat) 24367, (Mouse) 99571
protein polymerization
cell-matrix adhesion
blood coagulation
protein secretion
platelet activation
plasminogen activation
positive regulation of heterotypic cell-cell adhesion
fibrinolysis
positive regulation of vasoconstriction
positive regulation of exocytosis
positive regulation of protein secretion
response to calcium ion
protein-containing complex assembly
positive regulation of ERK1 and ERK2 cascade
platelet aggregation
blood coagulation, fibrin clot formation
positive regulation of peptide hormone secretion
positive regulation of substrate adhesion-dependent cell spreading
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of endothelial cell apoptotic process
platelet maturation
cellular response to interleukin-1
cellular response to interleukin-6
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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