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Invitrogen

ChREBP Polyclonal Antibody, DyLight™ 488

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ChREBP Polyclonal Antibody, DyLight™ 488

Product Details

PA5-22923

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-

Immunoprecipitation (IP)

Assay-dependent
-

ChIP assay (ChIP)

Assay-dependent
-

Gel Shift (EMSA)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A C-terminal synthetic peptide made to the human CHREBP protein sequence (between residues 800-852).
3D Epitope / Immunogen

Conjugate

DyLight™ 488 DyLight™ 488 DyLight™ 488

Excitation/Emission Max

492/519 nm View spectra spectra

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

50mM sodium borate

Contains

0.05% sodium azide

Storage conditions

4°C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11152706

Product Specific Information

The target sequence has 83% sequence homology with mouse ChREBP.

Target Information

ChREBP is a transcription factor involved in activating genes that encode enzymes of fatty acid biosynthesis in liver and adipose. This protein may have relevance to lipid metabolism, obesity, and type II diabetes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: bHLH transcription factor; bHLHZip transcription factor; carbohydrate response element binding protein; ChREBP beta; class D basic helix-loop-helix protein 14; Max-like protein; MLX interacting protein-like beta; MLX interactor; putative hepatic transcription factor; unnamed protein product; Williams Beuren syndrome chromosome region 14; Williams-Beuren syndrome chromosomal region 14 protein; Williams-Beuren syndrome chromosome region 14 homolog; Williams-Beuren syndrome chromosome region 14 protein 1; Williams-Beuren syndrome chromosome region 14 protein 2; Williams-Beuren syndrome chromosome region 14 protein 3; WS basic-helix-loop-helix leucine zipper protein

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Gene Aliases: bHLHd14; CHREBP; MIO; Mlx; MONDOB; WBSCR14; WS-bHLH

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UniProt ID: (Human) Q9NP71, (Rat) Q8VIP2, (Mouse) Q99MZ3

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Entrez Gene ID: (Human) 51085, (Rat) 171078, (Mouse) 58805

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding carbohydrate response element binding protein homodimerization activity protein heterodimerization activity protein dimerization activity RNA polymerase II sequence-specific DNA binding transcription factor binding DNA-binding transcription factor binding protein binding protein kinase binding sequence-specific DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase II promoter by glucose regulation of glycolytic process regulation of transcription from RNA polymerase II promoter response to nutrient positive regulation of cell proliferation lipid biosynthetic process response to glucose glucose mediated signaling pathway response to nutrient levels response to vitamin B3 positive regulation of insulin secretion involved in cellular response to glucose stimulus glucose homeostasis positive regulation of fatty acid biosynthetic process positive regulation of glycolytic process negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of lipid biosynthetic process fatty acid homeostasis cellular response to glucose stimulus negative regulation of oxidative phosphorylation energy homeostasis negative regulation of signal transduction by p53 class mediator regulation of transcription, DNA-templated anatomical structure morphogenesis triglyceride homeostasis
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Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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