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Invitrogen
FZD10 Polyclonal Antibody
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Product Details
PA5-23159
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Non-human primate,
Sheep,
Pig
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A portion of amino acid 150-200 of human Frizzled-10.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum with 50% glycerol
Contains
0.025% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Sequence homology: Rat (88%).
Target Information
FZD10/Frizzled-10 is a 581 amino acid protein belonging to the G-protein coupled receptor Fz/Smo family and containing a signal peptide, a cysteine-rich domain in the N-terminal, seven transmembrane domains and a C-terminal PDZ domain-binding motif. It is involved in transduction, intercellular transmission of polarity information during tissue morphogenesis in differentiated tissues and as a receptor for Wnt proteins. FZD10 is expressed highly in placenta, fetal kidney, fetal lung, brain cerebellum, cerebral cortex, medulla and spinal cord with very low levels in total brain, frontal lobe, temporal lobe, putamen, adult brain, heart, lung and skeletal muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD350; CD350 antigen; frizzled 10, seven transmembrane spanning receptor; frizzled family receptor 10; frizzled homolog 10; Frizzled-10; Fz-10; FzE7
Gene Aliases: CD350; FZ-10; Fz10; FZD10; FzE7; hFz10
UniProt ID: (Human) Q9ULW2, (Mouse) Q8BKG4
Entrez Gene ID: (Pig) 100511782, (Bovine) 515323, (Human) 11211, (Sheep) 101118991, (Mouse) 93897
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
Wnt signaling pathway
neuron differentiation
regulation of actin cytoskeleton organization
non-canonical Wnt signaling pathway
positive regulation of JNK cascade
canonical Wnt signaling pathway
cellular response to retinoic acid
multicellular organism development
negative regulation of GTPase activity
non-canonical Wnt signaling pathway via JNK cascade
positive regulation of JUN kinase activity
positive regulation of GTPase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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