Search
Invitrogen
OPRM1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 6
OPRM1 Antibody (PA5-26138) in IHC (P)
Immunohistochemistry analysis of OPRM1 in formalin fixed and paraffin embedded human brain tissue. Samples were incubated with OPRM1 polyclonal antibody (Product # PA5-26138) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-26138
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 161-187 amino acids from the central region of human OPRM1
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
200 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with porcine, non-human primate and rat based on sequence homology.
Target Information
The OPRM1 gene encodes the mu opioid receptor, which is the primary site of action for the most commonly used opioids, including morphine, heroin, fentanyl, and methadone. It is also the primary receptor for endogenous opioid peptides beta-endorphin and the enkephalins. The OPRM1 receptor is a membrane of the G protein-coupled receptor family. There are at least 3 types of opioid receptors, mu, kappa, and delta, each with a distinct pharmacologic profile.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: exon 1 splice variant; exon 4 splice variant; G-protein coupled receptor; GPCR; GPCR; MOR-1K1; hMOP; KIAA0403; MOP receptor; MOR-1; MOR-1A; MOR-1BI; MOR-1BII; MOR-1C; MOR-1CII; alternatively spliced; MOR-1Eiii; MOR-1Eiv; MOR-1F; MOR-1P; MOR-1Q; MOR-1R; MOR-1T; MOR-1U; MOR1; MOR3; Mu class opiate receptor; mu opiate receptor; mu opioid receptor hMOR-1a; mu opioid receptor MOR-1BI; mu opioid receptor MOR-1P; Opioid mu receptor; Opioid Receptor; OTTHUMP00000017463; unnamed protein product
Gene Aliases: LMOR; M-OR-1; MOP; MOP-R; MOR; MOR-1; MOR-1O; MOR1; muOR; OPRM
UniProt ID: (Human) P35372, (Mouse) P42866
Entrez Gene ID: (Human) 4988, (Mouse) 18390
G-protein alpha-subunit binding
G-protein coupled receptor activity
beta-endorphin receptor activity
opioid receptor activity
voltage-gated calcium channel activity
protein binding
G-protein coupled peptide receptor activity
G-protein beta-subunit binding
morphine receptor activity
neuropeptide binding
protein domain specific binding
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
sensory perception
negative regulation of cell proliferation
transmission of nerve impulse
sensory perception of pain
opioid receptor signaling pathway
negative regulation of nitric oxide biosynthetic process
behavioral response to ethanol
positive regulation of neurogenesis
negative regulation of cytosolic calcium ion concentration
negative regulation of Wnt protein secretion
positive regulation of ERK1 and ERK2 cascade
calcium ion transmembrane transport
cellular response to morphine
regulation of cellular response to stress
presynaptic modulation of chemical synaptic transmission
regulation of N-methyl-D-aspartate selective glutamate receptor activity
adenylate cyclase-activating dopamine receptor signaling pathway
locomotory behavior
adenylate cyclase-inhibiting opioid receptor signaling pathway
positive regulation of appetite
negative regulation of luteinizing hormone secretion
social behavior
sperm ejaculation
eating behavior
response to ethanol
positive regulation of gluconeogenesis
excitatory postsynaptic potential
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support