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Invitrogen
Staufen Polyclonal Antibody
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FIGURE: 1 / 4
Staufen Antibody (PA5-28479) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of Staufen was performed in DIV9 rat E18 primary hippocampal neuron cells fixed in 4% paraformaldehyde at RT for 15 min. Green: Staufen Polyclonal Antibody (Product # PA5-28479) diluted at 1:500. Red: beta Tubulin 3/ Tuj1, stained by beta Tubulin 3/ Tuj1 antibody. Blue: Fluoroshield with DAPI.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-28479
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the C-terminus region of human Staufen. The exact sequence is proprietary.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.93 mg/mL
Amount
93 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: 293T, A431, H1299, HepG2, Molt-4, Raji, Neuro2A, 293 (input), Stau1-IP (GTX106566), Post-IP lysate from control rabbit IgG-IP, Post-IP lysate from Stau1-IP.
Predicted reactivity: Mouse (95%), Rat (94%), Zebrafish (83%), Xenopus laevis (86%), Chicken (94%), Rhesus Monkey (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
STAU1 is a member of a family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human STAU1 also contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. STAU1 has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER. STAU1 is also known to interact with influenza ribonucleoproteins NS1, NP, and PA and is required for efficient viral replication.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: maternal effect protein; protein phosphatase 1, regulatory subunit 150; RNA binding protein; alternatively spliced; RP3-470L14.2; staufen (RNA binding protein) homolog 1; staufen, RNA binding protein, homolog 1; staufen; double-stranded RNA-binding protein; alternatively spliced; unnamed protein product
Gene Aliases: 5830401L18Rik; PPP1R150; STAU
UniProt ID: (Human) O95793, (Mouse) Q9Z108
Entrez Gene ID: (Human) 6780, (Mouse) 20853
germ cell development
intracellular mRNA localization
protein localization to synapse
positive regulation of viral genome replication
positive regulation by virus of viral protein levels in host cell
modulation of synaptic transmission
dendritic transport
dendritic transport of messenger ribonucleoprotein complex
anterograde dendritic transport of messenger ribonucleoprotein complex
modification of postsynaptic structure
positive regulation of long-term synaptic potentiation
lncRNA-mediated post-transcriptional gene silencing
cellular response to oxidative stress
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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