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Invitrogen
SHANK1 Polyclonal Antibody
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FIGURE: 1 / 7
SHANK1 Antibody (PA5-28633) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of SHANK1 was performed in DIV9 rat E18 primary cortical neurons fixed in 4% paraformaldehyde at RT for 15 min. Green: SHANK1 Polyclonal Antibody (Product # PA5-28633) diluted at 1:500. Red: beta Tubulin 3/ Tuj1, a neuron cell marker. Blue: Fluoroshield with DAPI.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-28633
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human SHANK1. The exact sequence is proprietary.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.53 mg/mL
Amount
53 µg
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: 293T, A431, HeLa, HepG2.
Predicted reactivity: Mouse (100%), Rat (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: brain specific protein; GKAP/SAPAP-interacting protein; multidomain postsynaptic density protein; OTTHUMP00000174437; postsynaptic density protein; postsynaptic scaffold protein; SAPAP-interacting protein synamon; SH3/ankyrin domain gene 1; SHANK 1; somatostatin receptor-interacting protein; SPANK 1; SPANK-1; SSTR-interacting protein; synamon
Gene Aliases: Shank1a; SPANK-1; Spank1; SSTRIP; synamon
UniProt ID: (Human) Q9Y566, (Rat) Q9WV48, (Mouse) D3YZU1
Entrez Gene ID: (Human) 50944, (Rat) 78957, (Mouse) 243961
G-protein coupled receptor binding
protein binding
SH3 domain binding
receptor signaling complex scaffold activity
GKAP/Homer scaffold activity
somatostatin receptor binding
ionotropic glutamate receptor binding
identical protein binding
macromolecular complex binding
ankyrin repeat binding
scaffold protein binding
structural constituent of postsynaptic density
long-term memory
associative learning
adult behavior
negative regulation of actin filament bundle assembly
social behavior
protein localization to synapse
olfactory behavior
habituation
modulation of synaptic transmission
synapse organization
neuromuscular process controlling balance
determination of affect
righting reflex
synapse maturation
dendritic spine morphogenesis
positive regulation of dendritic spine development
protein-containing complex assembly
vocalization behavior
AMPA selective glutamate receptor signaling pathway
maintenance of postsynaptic density structure
positive regulation of excitatory postsynaptic potential
cognition
memory
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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