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Invitrogen
HSP90 alpha Polyclonal Antibody
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FIGURE: 1 / 14
HSP90 alpha Antibody (PA5-29042) in ICC/IF
Immunofluorescence analysis of HSP90 alpha was performed using 70% confluent log phase HeLa cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with HSP90 alpha Polyclonal Antibody (Product # PA5-29042) at 5 µg/mL in 0.1% BSA and incubated overnight at 4 degre... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-29042
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Fruit fly,
Human,
Mouse,
Non-human primate,
Nematode,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human Hsp90 alpha. The exact sequence is proprietary.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.83 mg/mL
Amount
83 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: 293T, A431, HeLa, HepG2, mouse brain, rat brain, RK3E.
Predicted reactivity: Mouse (98%), Rat (98%), Pig (99%), Chicken (90%), Rhesus Monkey (99%), Chimpanzee (99%), Bovine (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Heat shock proteins (HSP) are proteins that are expressed in response to various biological stress, including heat. HSP90 is a 90 kDa protein that is induced under stress conditions, but is also one of the most abundant cellular proteins found under non-stress conditions. HSP90 has been found to be associated with a number of other intracellular proteins, including steroid receptors, actin, tubulin, and some kinases. It has been suggested that HSP90 is necessary to maintain structural integrity of at least some steroid receptors to allow for ligand binding during receptor activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Heat shock 86 kDa; Heat shock protein; heat shock protein 1, alpha; heat shock protein 86; heat shock protein 90kDa alpha (cytosolic), class A member 1; Heat shock protein family C member 1; Heat shock protein HSP 90-alpha; heat shock protein, 1; heat shock protein, 86 kDa 1; heat shock protein, 89 kDa; Heat shock protein90; HSP; HSP 86; HSP 90 alpha; HSP86; LAP-2; Lipopolysaccharide-associated protein 2; Renal carcinoma antigen NY-REN-38; TSTA; Tumor-specific transplantation 86 kDa antigen
Gene Aliases: 86kDa; 89kDa; AL024080; AL024147; hsp4; Hsp86; Hsp86-1; Hsp89; Hsp90; HSP90A; HSP90AA1; HSPC1; HSPCA
UniProt ID: (Mouse) P07901, (Rat) P82995
Entrez Gene ID: (Mouse) 15519, (Rat) 299331
nucleotide binding
UTP binding
CTP binding
mRNA binding
protein binding
ATP binding
GTP binding
ATPase activity
sulfonylurea receptor binding
protein kinase binding
protein phosphatase binding
MHC class II protein complex binding
nitric-oxide synthase regulator activity
TPR domain binding
dATP binding
identical protein binding
protein homodimerization activity
ion channel binding
poly(A) RNA binding
GTPase binding
Rho GDP-dissociation inhibitor binding
unfolded protein binding
Hsp90 family chaperone
neuron migration
protein folding
nitric oxide biosynthetic process
response to stress
response to unfolded protein
positive regulation of lamellipodium assembly
positive regulation of protein import into nucleus, translocation
protein refolding
protein import into mitochondrial outer membrane
positive regulation of nitric oxide biosynthetic process
positive regulation of cytotoxic T cell differentiation
positive regulation of cell size
regulation of catalytic activity
chaperone-mediated protein complex assembly
skeletal muscle contraction
response to heat
response to salt stress
cardiac muscle cell apoptotic process
response to estrogen
positive regulation of cardiac muscle contraction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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