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Invitrogen
ANP Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-29559
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Full length human ANP Recombinant protein.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.44 mg/mL
Amount
44 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 1% BSA, 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: mouse heart, rat heart.
Predicted reactivity: Mouse (80%), Rat (80%), Dog (85%), Pig (87%), Rabbit (81%), Bovine (85%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: atrial natriuretic factor; atrial natriuretic factor prohormone; atrial natriuretic peptide prohormone; atriopeptigen; atriopeptin; cardiodilatin; cardiodilatin-related peptide; cardionatrin; natriuretic peptide precursor A; Natriuretic peptide precursor A (pronatriodilatin, also Anf, Pnd); natriuretic peptide precursor type A; preproANF; preproANP; preprocardiodilatin-atrial natriuretic factor; preproCDD-ANF; prepronatiodilatin (PND); prepronatriodilatin; proANF; proANP; Pronatriodilatin; unnamed protein product; urodilatin
Gene Aliases: ANF; ANP; ATFB6; ATRST2; CDD; CDD-ANF; CDP; PND; RATANF
UniProt ID: (Human) P01160, (Mouse) P05125, (Rat) P01161
Entrez Gene ID: (Human) 4878, (Mouse) 230899, (Rat) 24602
response to hypoxia
system process
negative regulation of systemic arterial blood pressure
cGMP biosynthetic process
protein folding
receptor guanylyl cyclase signaling pathway
neuropeptide signaling pathway
female pregnancy
regulation of blood pressure
positive regulation of heart rate
cardiac muscle hypertrophy in response to stress
negative regulation of cell growth
response to insulin
sodium ion export from cell
negative regulation of epidermal growth factor receptor signaling pathway
regulation of vascular permeability
negative regulation of JUN kinase activity
negative regulation of blood pressure
cGMP metabolic process
regulation of atrial cardiac muscle cell membrane repolarization
positive regulation of cardiac muscle contraction
cell growth involved in cardiac muscle cell development
cellular response to hydrogen peroxide
cellular response to mechanical stimulus
cellular response to glucose stimulus
negative regulation of canonical Wnt signaling pathway
synaptic signaling via neuropeptide
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
positive regulation of potassium ion export across plasma membrane
negative regulation of collecting lymphatic vessel constriction
cellular response to angiotensin
response to 3-methylcholanthrene
cardiac conduction system development
aortic valve morphogenesis
response to muscle stretch
heart development
regulation of body fluid levels
multicellular organismal water homeostasis
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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