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Invitrogen

Filamin A alpha-2 Polyclonal Antibody

1 Published Figure
1 Reference

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Filamin A alpha-2 Polyclonal Antibody

Product Details

PA5-29598

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the C-terminus region of human Filamin A. The exact sequence is proprietary.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.42 mg/mL

Amount

42 µg

Purification

Antigen affinity chromatography

Storage buffer

0.1M tris glycine, pH 7, with 20% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2547074

Product Specific Information

Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji, mouse kidney, PC-12, Rat2.

Predicted reactivity: Mouse (98%), Rat (98%), Rabbit (98%), Bovine (99%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: ABP-280; actin binding protein 280; Actin-binding protein 280; Alpha-filamin; dilated pupils 2; Endothelial actin-binding protein; Endothelial actin-binding protein 280); epididymis secretory sperm binding protein; filamin A, alpha; filamin, alpha; Filamin-1; Filamin-A; FLN-A; Non-muscle filamin; unnamed protein product

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Gene Aliases: ABP-280; ABPX; CSBS; CVD1; Dilp2; F730004A14Rik; FGS2; filamin-1; FLN; FLN-A; FLN1; FLNA; FMD; GENA 379; MNS; NHBP; OPD; OPD1; OPD2; RGD1560614; XLVD; XMVD

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UniProt ID: (Human) P21333, (Mouse) Q8BTM8

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Entrez Gene ID: (Human) 2316, (Rat) 293860, (Mouse) 192176

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Function(s)
G-protein coupled receptor binding RNA binding actin binding protein binding potassium channel regulator activity kinase binding small GTPase binding Fc-gamma receptor I complex binding protein homodimerization activity ion channel binding macromolecular complex binding cadherin binding SMAD binding actin filament binding GTPase binding DNA-binding transcription factor binding protein sequestering activity glycoprotein binding signal transducer activity protein kinase C binding transcription factor binding Rho GTPase binding Ral GTPase binding mu-type opioid receptor binding protein complex binding poly(A) RNA binding Rac GTPase binding
Process(es)
epithelial to mesenchymal transition adenylate cyclase-inhibiting dopamine receptor signaling pathway biological_process actin cytoskeleton organization actin cytoskeleton reorganization protein localization to cell surface negative regulation of protein catabolic process cilium assembly mRNA transcription from RNA polymerase II promoter positive regulation of transcription factor import into nucleus receptor clustering positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of sequence-specific DNA binding transcription factor activity early endosome to late endosome transport establishment of protein localization protein stabilization cytoplasmic sequestering of protein actin crosslink formation platelet aggregation mitotic spindle assembly negative regulation of transcription from RNA polymerase I promoter cell projection organization negative regulation of apoptotic process positive regulation of substrate adhesion-dependent cell spreading positive regulation of integrin-mediated signaling pathway blood coagulation, intrinsic pathway positive regulation of platelet activation formation of radial glial scaffolds cerebral cortex development regulation of cell migration positive regulation of actin filament bundle assembly megakaryocyte development positive regulation of protein import into nucleus wound healing, spreading of cells release of sequestered calcium ion into cytosol cilium morphogenesis semaphorin-plexin signaling pathway protein localization to plasma membrane tubulin deacetylation establishment of Sertoli cell barrier positive regulation of potassium ion transmembrane transport protein localization to bicellular tight junction regulation of membrane repolarization during atrial cardiac muscle cell action potential regulation of membrane repolarization during cardiac muscle cell action potential positive regulation of neural precursor cell proliferation positive regulation of neuron migration
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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