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Invitrogen
Phospho-MUNC18 (Ser241) Polyclonal Antibody
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FIGURE: 1 / 1
Phospho-MUNC18 (Ser241) Antibody (PA5-35398) in WB
Western blot of MUNC18 in mouse hippocampal lysate showing specific immunolabeling of a band at ~65 kDa corresponding to Phospho-MUNC18 (Ser241) polyclonal antibody (Product # PA5-35398) in the first lane (-). Phosphospecificity is shown in the second lane (+) where immunolabeling is completely eliminated by blot treatment with lambda phosphatase (1,200 units for 30 min).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-35398
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser241 of mouse STXBP1 conjugated to KLH
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.3 mg/mL
Amount
30 µg
Purification
Affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 50% glycerol, 0.1mg/mL BSA
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with bovine, canine, chicken, human, non-human primate, rat and sheep based on 100% sequence homology.
This antibody contains enough material to conduct 10 mini-Western blots.
Target Information
This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EIEE4; FLJ37475; hUNC18; MGC146482; minisatellite 10g detected by probe MMS10; munc-18c; n-sec1; p67; protein unc-18 homolog 1; protein unc-18 homolog A; rop; RP11-56D16.3; UNC-18 homolog; unc-18-1; unc-18A
Gene Aliases: ANC18HA; MMS10-G; Ms10g; Munc-18a; Munc18-1; N-sec1; nSec1; NSEC1A; Rb-sec1; rbSec1; rbSec1A; rbSec1B; Sec1; Sxtbp1; Unc18-1; Unc18h
UniProt ID: (Rat) P61765, (Mouse) O08599
Entrez Gene ID: (Rat) 25558, (Mouse) 20910
platelet degranulation
developmental process involved in reproduction
intracellular protein transport
exocytosis
neurotransmitter secretion
neuromuscular synaptic transmission
axon target recognition
regulation of synaptic vesicle priming
positive regulation of synaptic vesicle priming
synaptic vesicle priming
synaptic vesicle maturation
vesicle-mediated transport
negative regulation of protein complex assembly
regulation of vesicle fusion
positive regulation of vesicle fusion
negative regulation of synaptic transmission, GABAergic
response to estradiol
SNARE complex assembly
negative regulation of SNARE complex assembly
positive regulation of mast cell degranulation
negative regulation of neuron apoptotic process
positive regulation of exocytosis
positive regulation of calcium ion-dependent exocytosis
protein stabilization
long term synaptic depression
evoked neurotransmitter secretion
platelet aggregation
cellular response to interferon-gamma
protein localization to plasma membrane
presynaptic dense core vesicle exocytosis
positive regulation of glutamate secretion, neurotransmission
regulation of acrosomal vesicle exocytosis
synaptic vesicle fusion to presynaptic active zone membrane
positive regulation of regulated secretory pathway
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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