Search

  • Order Status
  • Quick Order
  • Promos

Invitrogen

FOXO1/FOXO3/FOXO4 Polyclonal Antibody

View all (10) FOXO1/FOXO3/FOXO4 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Datasheet
Certificates
Protocols
Questions & Answers
Datasheet
Certificates
Protocols
Questions & Answers
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}

Product Details

PA5-36084

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to the RPRSCTWPL of human FoxO1 (aa 19-27).

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2553362

Product Specific Information

This antibody detects endogenous protein at a molecular weight of 70-82 kDa.

Purity is >95% by SDS-PAGE.

Target Information

FOXO1 + FOX3 + FOX4 belong to the forkhead family of transcription factors. FOXO1 (FKHR or ForkHead in Rhabdomyosarcoma) is a 70 kDa protein. Recent studies have shown that this protein can act as either a coactivator or a corepressor of nuclear receptor activity. This action is mediated through the LXXLL motif found in the C terminus of the FOXO1A protein. The specific function of the gene has not yet been determined.FOX3 probably functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of the FOXO3 gene with the MLL gene is associated with secondary acute leukemia.FOX4 is a forkhead transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. FOXO4 down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is also involved in negative regulation of the cell cycle.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: AFX; AFX1; fork head domain transcription factor AFX1; forkhead box O1a; forkhead box O1A (rhabdomyosarcoma); forkhead box O3A; Forkhead box protein O1A; forkhead homolog (rhabdomyosarcoma) like 1; Forkhead in rhabdomyosarcoma; forkhead in rhabdomyosarcoma-like 1; forkhead protein; forkhead protein 1; forkhead protein FKHR2; forkhead, Drosophila, homolog of, in rhabdomyosarcoma; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1; FOX04b; FOXO3A-; member of FKHR-subclass forkhead/winged helix family; MGC120490; myeloid/lymphoid or mixed lineage-leukemia translocation to 7 homolog; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7; unnamed protein product

View more View less

Gene Aliases: 1110048B16Rik; 2010203A17Rik; AF6q21; AFX; AFX1; Afxh; FKH1; FKHR; Fkhr1; Fkhr2; FKHRL1; FKHRL1P2; FOXO1A; FOXO2; FOXO3A; MLLT7; RGD1561201

View more View less

UniProt ID: (Human) Q12778, (Human) O43524, (Human) P98177, (Rat) G3V7R4, (Mouse) Q9R1E0, (Mouse) Q9WVH4, (Mouse) Q9WVH3

View more View less

Entrez Gene ID: (Human) 2308, (Human) 2309, (Human) 4303, (Rat) 84482, (Mouse) 56458, (Mouse) 56484, (Rat) 294515, (Rat) 302415, (Mouse) 54601

View more View less

Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding beta-catenin binding chromatin DNA binding ubiquitin protein ligase binding sequence-specific DNA binding protein phosphatase 2A binding promoter-specific chromatin binding transcription regulatory region sequence-specific DNA binding transcription cofactor binding protein kinase binding mitochondrial RNA polymerase binding promoter specificity activity sequence-specific double-stranded DNA binding enzyme binding identical protein binding DNA-binding transcription factor binding transcription coactivator binding transcription factor binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter blood vessel development regulation of gluconeogenesis regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter apoptotic process cellular response to DNA damage stimulus insulin receptor signaling pathway cellular response to starvation gene expression positive regulation of autophagy negative regulation of gene expression peptidyl-serine phosphorylation peptidyl-threonine phosphorylation response to insulin cellular response to insulin stimulus negative regulation of stress-activated MAPK cascade positive regulation of smooth muscle cell apoptotic process cellular response to oxidative stress regulation of cell proliferation glucose homeostasis positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of fat cell differentiation positive regulation of gluconeogenesis positive regulation of protein catabolic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of insulin secretion regulation of transcription initiation from RNA polymerase II promoter enamel mineralization cellular response to hydrogen peroxide response to fatty acid cellular response to hyperoxia cellular response to dexamethasone stimulus cellular response to nitric oxide negative regulation of canonical Wnt signaling pathway neuronal stem cell population maintenance response to fluoride negative regulation of cardiac muscle hypertrophy in response to stress positive regulation of complement-dependent cytotoxicity regulation of neural precursor cell proliferation regulation of reactive oxygen species metabolic process response to oxidative stress mitotic G2 DNA damage checkpoint negative regulation of cell proliferation positive regulation of smooth muscle cell migration negative regulation of angiogenesis response to nutrient levels stem cell differentiation negative regulation of smooth muscle cell differentiation negative regulation of G0 to G1 transition response to water-immersion restraint stress ovulation from ovarian follicle initiation of primordial ovarian follicle growth antral ovarian follicle growth oocyte maturation transcription from mitochondrial promoter regulation of translation phagocytosis response to xenobiotic stimulus positive regulation of muscle atrophy DNA damage response, signal transduction by p53 class mediator negative regulation of cell migration tumor necrosis factor-mediated signaling pathway cellular response to glucose starvation response to starvation positive regulation of neuron apoptotic process positive regulation of regulatory T cell differentiation positive regulation of erythrocyte differentiation negative regulation of neuron differentiation brain morphogenesis cellular response to glucose stimulus cellular response to corticosterone stimulus response to dexamethasone extrinsic apoptotic signaling pathway in absence of ligand positive regulation of hydrogen peroxide-mediated programmed cell death positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of reactive oxygen species biosynthetic process cellular response to beta-amyloid cellular response to nerve growth factor stimulus positive regulation of endothelial cell apoptotic process temperature homeostasis cellular glucose homeostasis protein acetylation fat cell differentiation negative regulation of transcription, DNA-templated cellular response to cold energy homeostasis gluconeogenesis proteasome-mediated ubiquitin-dependent protein catabolic process protein K48-linked ubiquitination
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support