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Invitrogen

PDPK1/PDPK2/PDPK3 Polyclonal Antibody

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1 Published Figure
1 Reference
View all (5) PKD1/2/3/PKC mu antibodies

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PDPK1/PDPK2/PDPK3 Polyclonal Antibody

Product Details

PA5-36113

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to amino acids 708-763 of human PKD1
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2553375

Product Specific Information

This antibody detects endogenous protein at a molecular weight of 90-140 kDa.

Purity is >95% by SDS-PAGE.

Target Information

Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response. Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation. Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: nPKC-D1; nPKC-D2; nPKC-mu; nPKC-nu; PKC mu; PKD2; protein kinase C mu type; protein kinase C nu type; protein kinase C, mu; protein kinase C, nu; protein kinase D; protein kinase EPK2; unnamed protein product

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Gene Aliases: 4930557O20Rik; 5730497N19Rik; CHDED; EPK2; HSPC187; nPKC-D1; nPKC-D2; nPKC-mu; nPKC-NU; PKC-MU; PKC-NU; PKCM; Pkcnu; PKD; PKD1; PKD2; PKD3; PRKCM; PRKCN; RGD1308054

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UniProt ID: (Human) Q15139, (Human) Q9BZL6, (Human) O94806, (Mouse) Q62101, (Rat) Q9WTQ1, (Rat) Q5XIS9, (Mouse) Q8BZ03, (Mouse) Q8K1Y2

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Entrez Gene ID: (Human) 5587, (Human) 25865, (Human) 23683, (Mouse) 18760, (Rat) 85421, (Rat) 292658, (Mouse) 101540, (Mouse) 75292, (Rat) 313834

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Function(s)
protein kinase activity protein serine/threonine kinase activity protein kinase C activity calcium-independent protein kinase C activity protein kinase C binding protein binding ATP binding kinase activity heat shock protein binding identical protein binding protein serine kinase activity phosphatidylinositol 3-kinase activator activity nucleotide binding
Process(es)
positive regulation of endothelial cell proliferation protein phosphorylation phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of endothelial cell migration sphingolipid biosynthetic process positive regulation of vascular endothelial growth factor receptor signaling pathway positive regulation of interleukin-2 production positive regulation of interleukin-8 production intracellular signal transduction cellular response to vascular endothelial growth factor stimulus positive regulation of blood vessel endothelial cell migration positive regulation of fibroblast growth factor receptor signaling pathway positive regulation of angiogenesis positive regulation of cell adhesion positive regulation of transcription from RNA polymerase II promoter vascular endothelial growth factor receptor signaling pathway T cell receptor signaling pathway positive regulation of T cell receptor signaling pathway endothelial tube morphogenesis regulation of T cell apoptotic process positive regulation of ERK1 and ERK2 cascade positive regulation of DNA biosynthetic process positive regulation of endothelial cell chemotaxis Golgi organization signal transduction integrin-mediated signaling pathway positive regulation of autophagy positive regulation of gene expression regulation of keratinocyte proliferation positive regulation of neuron projection development regulation of skeletal muscle contraction by modulation of calcium ion sensitivity of myofibril cellular response to amino acid starvation cellular response to oxidative stress positive regulation of protein import into nucleus positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of osteoblast differentiation positive regulation of cell size negative regulation of endocytosis protein autophosphorylation positive regulation of protein export from nucleus Golgi vesicle transport defense response to Gram-negative bacterium positive regulation of protein kinase B signaling positive regulation of sarcomere organization transepithelial transport cellular response to hydroperoxide response to norepinephrine cellular response to norepinephrine stimulus positive regulation of peptide hormone secretion positive regulation of NLRP3 inflammasome complex assembly positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway cellular response to angiotensin cellular response to phorbol 13-acetate 12-myristate cellular response to endothelin regulation of integrin-mediated signaling pathway positive regulation of cell communication positive regulation of signaling positive regulation of peptidyl-serine phosphorylation cell-cell adhesion mediated by cadherin regulation of release of sequestered calcium ion into cytosol
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