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Invitrogen
ZIC1/ZIC2/ZIC3 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-36307
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 318-366 of human Zic1
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 51 kDa.
Purity is >95% by SDS-PAGE.
Target Information
Zic1 encodes a zinc finger protein expressed in the developing or matured central nervous system in a highly restricted manner. Zic is expressed in granule cells that make synaptic contact with Purkinje cells. Zic1 is a gene critical to cerebellar pattern formation. The expression of Zic genes is first detected at gastrulation and at neurulation, becoming restricted to the dorsal neural ectoderm and the dorsal paraxial mesoderm. The Zic1 gene has been mapped to chromosome 9 in mouse. The 5' flanking region of the Zic1 gene contains a region-specific enhancer determined to be essential in in-vivo and in-vitro deletion analysis. The temporal profile of mRNA expression differs for each of the Zic gene products. The Drosophila odd-paired gene is highly homologous to the Zic gene family. Zic2 and Zic3 are highly similar genes. Zic2 is essential for the formation of the brain and Zic-3 is important for right and left axis formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GENA 29; heterotaxy 1; kumba; odd-paired homolog; transcription factor; unnamed protein product; Zic family member 1 (odd-paired homolog, Drosophila); Zic family member 2 (odd-paired homolog, Drosophila); Zic family member 3 (odd-paired homolog, Drosophila); zic protein member 1; zinc finger protein 201; zinc finger protein 203; Zinc finger protein of the cerebellum 1; Zinc finger protein of the cerebellum 2; zinc finger protein of the cerebellum 3
Gene Aliases: BAIDCS; Bn; CRS6; HPE5; HTX; HTX1; Ka; Ku; RGD1561261; VACTERLX; ZIC; ZNF201; ZNF203
UniProt ID: (Human) Q15915, (Human) O95409, (Human) O60481, (Mouse) P46684, (Mouse) Q62521
Entrez Gene ID: (Human) 7545, (Human) 7546, (Human) 7547, (Rat) 64618, (Mouse) 22771, (Rat) 361096, (Mouse) 22772, (Mouse) 22773, (Rat) 367944
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
protein binding
promoter-enhancer loop anchoring activity
sequence-specific double-stranded DNA binding
DNA binding
chromatin DNA binding
transcription coactivator activity
sequence-specific DNA binding
promoter-specific chromatin binding
neural plate development
neural tube closure
regulation of transcription from RNA polymerase II promoter
nervous system development
central nervous system development
visual perception
biological_process
gene expression
cell differentiation
retinal ganglion cell axon guidance
central nervous system segmentation
nodal signaling pathway
cilium organization
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
developmental pigmentation
axial mesoderm development
paraxial mesoderm development
brain development
skeletal system development
heart looping
atrial cardiac muscle tissue development
smoothened signaling pathway
determination of left/right symmetry
gastrulation
mesoderm development
heart development
embryonic pattern specification
stem cell population maintenance
hippocampus development
olfactory bulb development
neuron differentiation
lung development
germ-line stem cell population maintenance
forebrain development
limb morphogenesis
determination of pancreatic left/right asymmetry
determination of left/right asymmetry in nervous system
outer ear morphogenesis
mRNA transcription from RNA polymerase II promoter
stem cell differentiation
face development
left/right pattern formation
left/right axis specification
determination of digestive tract left/right asymmetry
determination of liver left/right asymmetry
primitive streak formation
maintenance of cell number
cranial skeletal system development
pattern specification process
adult walking behavior
regulation of smoothened signaling pathway
spinal cord development
positive regulation of protein import into nucleus
inner ear morphogenesis
anterior/posterior pattern specification
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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