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Invitrogen
mGluR2/mGluR3 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-36519
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 836-872 of Human mGluR-2.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 95 kDa.
Purity is >95% by SDS-PAGE.
Target Information
The mGluR proteins (metabotropic Glutamate Receptors) are members of the G-protein-coupled receptor family and are functionally and pharmacologically distinct from the GluR proteins (ionotropic Glutamate Receptors). The eight currently known mGluR proteins are mediated by two G-proteins with opposing regulation of adenylate cyclase pathways. The activities of mGluR1 and mGluR5 are mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. The remainder of the eight sub-types of mGluR have an activity mediated by a G-protein that inhibits adenylate cyclase activity. mGluR-3, which may interact with GRASP, acts as a receptor for glutamate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: G protein-coupled receptor; G protein-coupled receptor GRM2; G protein-coupled receptor, family C, group 1, member B; G protein-coupled receptor, family C, group 1, member C; glutamate receptor; glutamate receptor homolog; glutamate receptor, metabotropic 2; glutamate receptor, metabotropic 3; M mGlu3; mGluR2; mGluR3; unnamed protein product
Gene Aliases: 0710001G23Rik; 4930441L02Rik; GLUR2; GLUR3; GPRC1B; GPRC1C; mGlu2; mGlu3; MGLUR2; MGLUR3; mGluR7
UniProt ID: (Human) Q14416, (Human) Q14832, (Rat) P31421, (Mouse) Q14BI2, (Mouse) Q9QYS2, (Rat) P31422
Entrez Gene ID: (Human) 2912, (Human) 2913, (Rat) 24415, (Mouse) 108068, (Mouse) 108069, (Rat) 24416
G-protein coupled receptor signaling pathway
negative regulation of adenylate cyclase activity
adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
G-protein coupled glutamate receptor signaling pathway
chemical synaptic transmission
modulation of synaptic transmission
regulation of synaptic transmission, glutamatergic
postsynaptic modulation of chemical synaptic transmission
glutamate receptor signaling pathway
gene expression
glutamate secretion
regulation of glutamate secretion
regulation of dopamine secretion
cellular response to stress
behavioral response to nicotine
response to cocaine
regulation of neurotransmitter secretion
positive regulation of protein kinase B signaling
long term synaptic depression
glutamate homeostasis
presynaptic modulation of chemical synaptic transmission
regulation of response to drug
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
sensory perception of pain
synaptic transmission, glutamatergic
regulation of sensory perception of pain
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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