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Invitrogen
Phospho-ATP1A1 (Ser16) Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-36732
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic phosphopeptide derived from human Na+/K+-ATPase alpha1 around the phosphorylation site of Serine 16
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 112 kDa.
Purity is >95% by SDS-PAGE.
Target Information
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: (Na+ and K+) ATPase, alpha catalytic subunit precursor; ATP1B; ATPase, Na+/K+ transporting, alpha 1 polypeptide; ATPase, Na+K+ transporting, alpha 1; G00-119-711; MGC1798; Na(+)/K(+) ATPase alpha-1 subunit; Na+ K+ ATPase alpha subunit; Na+/K+ ATPase 1; Na+/K+ ATPase Alpha; Na, K-ATPase, alpha-A catalytic polypeptide; Na,K-ATPase alpha-1 subunit; Na,K-ATPase catalytic subunit alpha-A protein; Na,K-ATPase, alpha-subunit; RP4-655J12.1; Sodium Potassium ATPase; sodium pump subunit alpha-1; sodium-potassium ATPase catalytic subunit alpha-1; sodium-potassium-ATPase, alpha 1 polypeptide; unnamed protein product
Gene Aliases: Atpa-1; CMT2DD; HOMGSMR2; Nkaa1b
UniProt ID: (Human) P05023, (Mouse) Q8VDN2, (Rat) P06685
Entrez Gene ID: (Human) 476, (Mouse) 11928, (Rat) 24211
nucleotide binding
sodium:potassium-exchanging ATPase activity
protein binding
ATP binding
potassium-transporting ATPase activity
phosphatase activity
ATPase activity
potassium ion binding
sodium ion binding
ion channel binding
chaperone binding
steroid hormone binding
protein kinase binding
protein domain specific binding
ankyrin binding
ADP binding
phosphatidylinositol 3-kinase binding
protein heterodimerization activity
ATPase binding
regulation of the force of heart contraction
regulation of sodium ion transport
potassium ion transport
sodium ion transport
cellular sodium ion homeostasis
osmosensory signaling pathway
regulation of blood pressure
response to xenobiotic stimulus
establishment or maintenance of transmembrane electrochemical gradient
cellular potassium ion homeostasis
negative regulation of glucocorticoid biosynthetic process
sodium ion transmembrane transport
sodium ion export from cell
negative regulation of heart contraction
positive regulation of heart contraction
positive regulation of striated muscle contraction
sodium ion homeostasis
transmembrane transport
membrane hyperpolarization
cellular response to mechanical stimulus
cellular response to steroid hormone stimulus
potassium ion transmembrane transport
regulation of cardiac muscle cell contraction
membrane repolarization
hydrogen ion transmembrane transport
response to glycoside
potassium ion import across plasma membrane
energy coupled proton transmembrane transport, against electrochemical gradient
relaxation of cardiac muscle
cardiac muscle contraction
cellular cation homeostasis
cardiac muscle cell action potential involved in contraction
membrane repolarization during cardiac muscle cell action potential
cell communication by electrical coupling involved in cardiac conduction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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