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Invitrogen

Phospho-CDK1 (Thr14) Polyclonal Antibody

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Phospho-CDK1 (Thr14) Polyclonal Antibody

Product Details

PA5-37516

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide sequence around phospho rylation site of threonine14(E-G-T(p)-Y-G) derived from Human CDK1/CDC2.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2554125

Product Specific Information

A suggested positive control for Western blot is HepG2 cells.

Target Information

CDK1 or Cell Division Control protein 1 is essential for the completion of START, the controlling event in the cell cycle that is required to initiate mitosis. CDK1 is a catalytic subunit of a protein kinase complex, called the M-Phase Promoting Factor that induces entry into mitosis and is universal among eukaryotes. Phosphorylation of Bcl-2 in G2/M phase-arrested cells following photodynamic therapy with hypericin involves a CDK1-mediated signal and delays the onset of apoptosis. Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer has also been demonstrated.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ABL1; cell cycle controller CDC2; cell cycle p34 CDC2 kinase protein; cell division control protein 2 homolog; cell division cycle 2 homolog A; cell division cycle 2, G1 to S and G2 to M; Cell division cycle control protein 2; cell division cycle control protein 2a; cell division protein kinase 1; DKFZp686L20222; KCIP-1; MGC111195; MGC53829; OTTHUMP00000019660; P34 CDK1; P34 MGC111195; p34 protein kinase; Protein 1054; unnamed protein product

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Gene Aliases: CDC2; CDC28A; Cdc2a; p34; P34CDC2

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UniProt ID: (Human) P06493, (Mouse) P11440, (Rat) P39951

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Entrez Gene ID: (Human) 983, (Mouse) 12534, (Rat) 54237

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Function(s)
chromatin binding protein kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity protein binding ATP binding RNA polymerase II carboxy-terminal domain kinase activity kinase activity cyclin binding Hsp70 protein binding histone kinase activity cyclin-dependent protein kinase activity protein serine kinase activity
Process(es)
G1/S transition of mitotic cell cycle G2/M transition of mitotic cell cycle microtubule cytoskeleton organization DNA replication DNA repair chromatin remodeling regulation of transcription from RNA polymerase II promoter cellular response to DNA damage stimulus mitotic nuclear envelope disassembly mitotic G2 DNA damage checkpoint centrosome cycle pronuclear fusion response to toxic substance positive regulation of gene expression positive regulation of G2/M transition of mitotic cell cycle regulation of Schwann cell differentiation response to amine response to activity cell migration protein deubiquitination peptidyl-threonine phosphorylation chromosome condensation epithelial cell differentiation negative regulation of protein ubiquitination protein localization to kinetochore positive regulation of protein import into nucleus response to hydrogen peroxide regulation of circadian rhythm negative regulation of apoptotic process response to ethanol positive regulation of DNA replication positive regulation of smoothened signaling pathway regulation of embryonic development response to cadmium ion response to copper ion response to axon injury ventricular cardiac muscle cell development positive regulation of cardiac muscle cell proliferation positive regulation of mitotic sister chromatid segregation protein-containing complex assembly cellular response to hydrogen peroxide ERK1 and ERK2 cascade Golgi disassembly regulation of heterochromatin organization positive regulation of protein localization to nucleus regulation of mitotic attachment of spindle microtubules to kinetochore microtubule cytoskeleton organization involved in mitosis positive regulation of mitochondrial ATP synthesis coupled electron transport positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process protein phosphorylation nuclear envelope organization cell proliferation negative regulation of gene expression peptidyl-serine phosphorylation mitotic cell cycle phase transition thymidine biosynthetic process microtubule polymerization cilium disassembly DNA strand resection involved in replication fork processing DNA synthesis involved in mitotic DNA replication protein localization to site of double-strand break mitotic DNA-dependent DNA replication meiotic spindle organization meiotic cell cycle process involved in oocyte maturation positive regulation of meiotic cell cycle process involved in oocyte maturation
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