Search

  • Order Status
  • Quick Order
  • Promos

Invitrogen

Phospho-FLT3 (Tyr842) Polyclonal Antibody

View all (69) FLT3 (CD135) antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Datasheet
Certificates
Protocols
Questions & Answers
Datasheet
Certificates
Protocols
Questions & Answers
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
Phospho-FLT3 (Tyr842) Polyclonal Antibody

Product Details

PA5-37580

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide sequence around phosphorylation site of tyrosine 842(S-N-Y(p)-V-V) derived from Human FLT3.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2554188

Product Specific Information

A suggested positive control for Western blot is HepG2 cells.

Target Information

FLT3 is a tyrosine protein kinase that is a member of the growth factor receptor tyrosine kinase family. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: CD135 antigen; fetal liver kinase 2; FL cytokine receptor; flk-2; fms related tyrosine kinase 3; fms-like tyrosine kinase 3; growth factor receptor tyrosine kinase type III; OTTHUMP00000214829; RP11-153M24.3; stem cell tyrosine kinase 1; tyrosine-protein kinase FLT3; tyrosine-protein kinase receptor flk-2; unnamed protein product

View more View less

Gene Aliases: B230315G04; CD135; FLK-2; FLK2; Flt-3; Ly72; STK1; wmfl

View more View less

UniProt ID: (Human) P36888, (Mouse) Q00342

View more View less

Entrez Gene ID: (Human) 2322, (Mouse) 14255

View more View less

Function(s)
protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane signaling receptor activity cytokine receptor activity vascular endothelial growth factor-activated receptor activity protein binding ATP binding growth factor binding glucocorticoid receptor binding macromolecular complex binding phosphatidylinositol 3-kinase activator activity ubiquitin protein ligase binding phosphatidylinositol 3-kinase binding
Process(es)
leukocyte homeostasis positive regulation of protein phosphorylation myeloid progenitor cell differentiation lymphoid progenitor cell differentiation pro-B cell differentiation pro-T cell differentiation cell surface receptor signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cell proliferation negative regulation of cell proliferation post-embryonic development cell migration cytokine-mediated signaling pathway antigen processing and presentation hemopoiesis lymphocyte differentiation B cell differentiation negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production positive regulation of interferon-alpha production positive regulation of interferon-gamma production positive regulation of interleukin-12 production common myeloid progenitor cell proliferation dendritic cell homeostasis positive regulation of multicellular organism growth negative regulation of B cell differentiation lymphocyte proliferation protein autophosphorylation lymph node development spleen development homeostasis of number of cells within a tissue regulation of developmental process cellular response to cytokine stimulus dendritic cell differentiation cellular response to virus peptidyl-tyrosine phosphorylation vascular endothelial growth factor signaling pathway positive regulation of tyrosine phosphorylation of STAT protein regulation of apoptotic process positive regulation of MAP kinase activity positive regulation of MAPK cascade positive regulation of protein kinase B signaling cellular response to glucocorticoid stimulus liver regeneration
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support