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Invitrogen
Phospho-STK39 (Ser323) Polyclonal Antibody
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FIGURE: 1 / 1
Phospho-STK39 (Ser323) Antibody (PA5-37793) in IHC (P)
Immunohistochemical analysis of Phospho-STK39 (Ser323) in paraffin-embedded Human brain tissue using Phospho-STK39 (Ser323) Polyclonal Antibody (Product # PA5-37793) (left) or the same antibody preincubated with blocking peptide (right).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-37793
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide sequence around phosphorylation site of Serine 323(D-P-S(p)-K-R) derived from Human STK39.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control for IHC is human brain tissue.
Target Information
STK39 (STLK3) is involved in the cellular stress response pathway. STK39 is activated in response to hypotonic stress leading to phosphorylation of several cation-chloride-coupled co-transporters. STK39 activates the p38 MAP kinase pathway and its interaction with p38 decreases during cellular stress. STK39 acts as an intermediate in the response to cellular stress. STK39 is also an independent risk factor for hypertension in men and its intragenic SNPs can interact and function in the control of blood pressure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp686K05124; serine threonine kinase 39 (STE20/SPS1 homolog, yeast); serine-threonine kinase; serine/threonine kinase homolog; serine/threonine-protein kinase 39; small intestine SPAK-like kinase; ste-20-related kinase; Ste20-like protein kinase; STE20/SPS1 homolog; STE20/SPS1-related proline/alanine-rich kinase
Gene Aliases: DCHT; SPAK
UniProt ID: (Human) Q9UEW8
Entrez Gene ID: (Human) 27347
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
potassium channel inhibitor activity
protein kinase binding
ion channel binding
scaffold protein binding
ion channel regulator activity
protein serine kinase activity
transporter regulator activity
transporter activator activity
transporter inhibitor activity
response to dietary excess
protein phosphorylation
cell volume homeostasis
inflammatory response
signal transduction
positive regulation of T cell chemotaxis
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
cellular chloride ion homeostasis
negative regulation of transmembrane transport
intracellular signal transduction
sodium ion transmembrane transport
cellular response to potassium ion
maintenance of lens transparency
chemokine (C-X-C motif) ligand 12 signaling pathway
macrophage activation
positive regulation of potassium ion transport
protein autophosphorylation
renal sodium ion absorption
cellular hyperosmotic response
cellular hypotonic response
negative regulation of pancreatic juice secretion
positive regulation of p38MAPK cascade
regulation of potassium ion transmembrane transport
negative regulation of sodium ion transmembrane transport
positive regulation of potassium ion import
positive regulation of sodium ion import across plasma membrane
response to aldosterone
regulation of cation transmembrane transport
cellular response to chemokine
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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