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Invitrogen
Phospho-Ephrin B1/B2/B3 (Tyr324/311/318) Polyclonal Antibody
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FIGURE: 1 / 1
Phospho-Ephrin B1/B2/B3 (Tyr324/311/318) Antibody (PA5-37810) in IHC (P)
Immunohistochemical analysis of Phospho-Ephrin B1/B2/B3 (Tyr324) in paraffin-embedded Human brain tissue using Phospho-Ephrin B1/B2/B3 (Tyr324) Polyclonal Antibody (Product # PA5-37810) (left) or the same antibody preincubated with blocking peptide (right).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-37810
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide sequence around phosphorylation site of tyrosine 324/311/318 (G-D-Y(p)-G-H) derived from Human Ephrin B1/B2/B3.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control for Western blot is K562 cells; suggested positive control for IHC is human brain tissue.
Target Information
Eph receptors and ephrins exhibit complementary expression in many tissues during embryogenesis indicating that bidirectional activation of Eph receptors and ephrin-B proteins may occur at expression domain interfaces. Ephrin-B1 transduces outside-in signals through C-terminal protein interactions that effect integrin-mediated cell attachment and migration. The distribution of ephrin-B1 in the developing retina suggests that it influences retinal axon mapping along the dorsal-ventral axis and may be involved in intratectal development The transmembrane ligand ephrin-B2 and its receptor tyrosine kinase EphB4 are specifically expressed on arterial and venous endothelial cells, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ELK ligand; EPH-related receptor transmembrane ligand ELK-L3; eph-related receptor tyrosine kinase ligand 2; eph-related receptor tyrosine kinase ligand 5; eph-related receptor tyrosine kinase ligand 8; HTK ligand; ligand of eph-related kinase 5; ligand of the eph-related receptor tyrosine kinases hek and elk; unnamed protein product
Gene Aliases: CFND; CFNS; EFB1; EFL3; EFL6; Elk-L; ephrin-B2; EPLG2; EPLG5; EPLG8; Htk-L; HTKL; LERK2; LERK5; LERK8
UniProt ID: (Human) P98172, (Human) P52799, (Human) Q15768
Entrez Gene ID: (Human) 1947, (Human) 1948, (Human) 1949
cell adhesion
cell-cell signaling
axon guidance
ephrin receptor signaling pathway
angiogenesis
cell migration involved in sprouting angiogenesis
positive regulation of cell proliferation
anatomical structure morphogenesis
negative regulation of neuron projection development
adherens junction organization
blood vessel morphogenesis
anatomical structure formation involved in morphogenesis
regulation of chemotaxis
cellular response to lipopolysaccharide
presynapse assembly
regulation of postsynaptic membrane neurotransmitter receptor levels
regulation of postsynaptic neurotransmitter receptor internalization
positive regulation of leukocyte adhesion to arterial endothelial cell
positive regulation of cardiac muscle cell differentiation
nervous system development
negative regulation of axonogenesis
trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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