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Phospho-EphA3/EphA4/EphA5 (Tyr779, Tyr833) Polyclonal Antibody

View all (2) EphA3/EphA4/EphA5 antibodies

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Phospho-EphA3/EphA4/EphA5 (Tyr779, Tyr833) Polyclonal Antibody

Product Details

PA5-37813

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:100
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide sequence around phosphorylation site of tyrosine 779/833 (E-A-Y(p)-T-T)/(Q-D-V(p)-I-K) derived from Human EPHA3/4/5.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2554421

Product Specific Information

A suggested positive control for IHC is human brain tissue.

Target Information

These proteins belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: brain-specific kinase; EPH homology kinase 1; EPH-like kinase 4; EPH-like kinase 7; EPH-like kinase 8; eph-like tyrosine kinase 1; epididymis secretory sperm binding protein; H TYRO4; human embryo kinase 1; receptor protein-tyrosine kinase HEK7; receptor protein-tyrosine kinase HEK8; soluble receptor; testicular tissue protein Li 64; TYRO1 protein tyrosine kinase; TYRO4 protein tyrosine kinase; tyrosine-protein kinase receptor EHK-1; tyrosine-protein kinase receptor ETK1; tyrosine-protein kinase receptor SEK; tyrosine-protein kinase TYRO1; unnamed protein product

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Gene Aliases: CEK7; EHK-1; EHK1; EK4; EK7; EK8; ETK; ETK1; HEK; HEK4; HEK7; HEK8; SEK; TYRO1; TYRO4

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UniProt ID: (Human) P29320, (Human) P54764, (Human) P54756

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Entrez Gene ID: (Human) 2042, (Human) 2043, (Human) 2044

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Function(s)
protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity ephrin receptor activity GPI-linked ephrin receptor activity transmembrane-ephrin receptor activity protein binding ATP binding beta-amyloid binding kinase activity PH domain binding identical protein binding ephrin receptor binding DH domain binding protein tyrosine kinase binding
Process(es)
transmembrane receptor protein tyrosine kinase signaling pathway axon guidance axonal fasciculation hippocampus development ephrin receptor signaling pathway neuron development negative regulation of insulin secretion involved in cellular response to glucose stimulus regulation of epithelial to mesenchymal transition negative regulation of epithelial to mesenchymal transition positive regulation of neuron projection development cell migration peptidyl-tyrosine phosphorylation regulation of cell-cell adhesion regulation of actin cytoskeleton organization negative regulation of endocytosis regulation of focal adhesion assembly regulation of microtubule cytoskeleton organization cellular response to retinoic acid fasciculation of sensory neuron axon fasciculation of motor neuron axon positive regulation of protein localization to plasma membrane negative regulation of cell adhesion motor neuron axon guidance positive regulation of cell proliferation glial cell migration negative regulation of neuron projection development negative regulation of translation corticospinal tract morphogenesis positive regulation of cell migration negative regulation of cell migration adherens junction organization regulation of GTPase activity positive regulation of cell adhesion positive regulation of JNK cascade negative regulation of axon regeneration regulation of astrocyte differentiation regulation of axonogenesis positive regulation of dendrite morphogenesis protein stabilization regulation of dendritic spine morphogenesis negative regulation of ERK1 and ERK2 cascade cochlea development neuron projection guidance synapse pruning neuron projection fasciculation negative regulation of cellular response to hypoxia negative regulation of long-term synaptic potentiation positive regulation of beta-amyloid formation positive regulation of intracellular signal transduction positive regulation of amyloid precursor protein catabolic process cellular response to beta-amyloid positive regulation of leukocyte adhesion to arterial endothelial cell regulation of modification of synaptic structure regulation of synapse pruning
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