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Invitrogen

Phospho-STAT5 alpha/beta (Ser725, Ser730) Polyclonal Antibody

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Phospho-STAT5 alpha/beta (Ser725, Ser730) Polyclonal Antibody

Product Details

PA5-37815

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide sequence around phosphorylation site of serine725/730(A-P-S(p)-P-V) derived from Human STAT5A/B.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2554423

Product Specific Information

A suggested positive control for Western blot is Jurkat cells.

Target Information

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor-associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of, many cell ligands, such as IL-2, IL-3, IL-7, GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/ BCL-X(L), which suggests the antiapoptotic function of this gene in cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: epididymis secretory sperm binding protein; STA5B; STAT; transcription factor STAT5B; unnamed protein product

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Gene Aliases: GHISID2; MGF; STAT5

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UniProt ID: (Human) P42229, (Human) P51692

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Entrez Gene ID: (Human) 6776, (Human) 6777

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding phosphate ion binding sequence-specific DNA binding DNA-binding transcription factor binding promoter-specific chromatin binding chromatin binding glucocorticoid receptor binding identical protein binding protein homodimerization activity protein dimerization activity
Process(es)
regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter defense response signal transduction JAK-STAT cascade cytokine-mediated signaling pathway taurine metabolic process response to estradiol cellular response to hormone stimulus erythropoietin-mediated signaling pathway regulation of multicellular organism growth regulation of cell proliferation response to peptide hormone positive regulation of erythrocyte differentiation positive regulation of transcription from RNA polymerase II promoter JAK-STAT cascade involved in growth hormone signaling pathway cellular response to growth factor stimulus cellular response to epidermal growth factor stimulus regulation of hemopoiesis positive regulation of endothelial cell proliferation eosinophil differentiation interleukin-15-mediated signaling pathway interleukin-4-mediated signaling pathway reelin-mediated signaling pathway interleukin-5-mediated signaling pathway interleukin-2-mediated signaling pathway interleukin-7-mediated signaling pathway interleukin-9-mediated signaling pathway interleukin-3-mediated signaling pathway thrombopoietin-mediated signaling pathway positive regulation of blood vessel endothelial cell migration negative regulation of T-helper 17 cell lineage commitment
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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