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Invitrogen

DLL1 Polyclonal Antibody

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DLL1 Polyclonal Antibody

Product Details

PA5-47556

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

0.5-15 µg/mL
-

Immunohistochemistry (Frozen) (IHC (F))

5-15 µg/mL
-

Flow Cytometry (Flow)

1 µg per million cells
-
Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Sheep / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Mouse myeloma cell line NS0-derived recombinant rat DLL1 Gln18-Trp537 (predicted)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.2 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2607385

Product Specific Information

In direct ELISAs, approximately 10% cross-reactivity with recombinant human DLL-1 is observed and less than 1% cross-reactivity with recombinant rat Notch-1 is observed.

Reconstitute at 0.2 mg/mL in sterile PBS.

Target Information

Delta-like protein 1 (DLL1) is a transmembrane protein characterized by epidermal growth factor (EGF)-like repeats. It is a ligand for Notch receptor. It blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: delta like-1; delta-like 1; delta1; drosophila Delta homolog 1; DSL ligand; OTTHUMP00000017690

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Gene Aliases: Delta1

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UniProt ID: (Rat) P97677, (Mouse) Q61483

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Entrez Gene ID: (Rat) 84010, (Mouse) 13388

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Function(s)
Notch binding calcium ion binding protein binding Tat protein binding receptor agonist activity scaffold protein binding
Process(es)
cell fate determination somitogenesis somite specification heart looping marginal zone B cell differentiation type B pancreatic cell development cell communication Notch signaling pathway cell-cell signaling determination of left/right symmetry compartment pattern specification nervous system development regulation of blood pressure positive regulation of cell proliferation negative regulation of cell proliferation auditory receptor cell fate commitment proximal/distal pattern formation positive regulation of gene expression astrocyte development regulation of somitogenesis spinal cord development cerebellar molecular layer formation cerebellar Purkinje cell layer structural organization regulation of cell adhesion negative regulation of epithelial cell differentiation regulation of vascular endothelial growth factor receptor signaling pathway negative regulation of interleukin-10 production negative regulation of glial cell apoptotic process organ growth regulation of growth cell fate commitment negative regulation of cell differentiation negative regulation of epidermal cell differentiation negative regulation of auditory receptor cell differentiation negative regulation of myeloid cell differentiation negative regulation of myoblast differentiation negative regulation of neuron differentiation negative regulation of Notch signaling pathway positive regulation of Notch signaling pathway positive regulation of endocytosis positive regulation of transcription from RNA polymerase II promoter lateral inhibition skeletal muscle tissue growth regulation of skeletal muscle tissue growth positive regulation of skeletal muscle tissue growth neuron fate specification inner ear development regulation of neurogenesis regulation of cell division retina development in camera-type eye retina morphogenesis in camera-type eye Notch signaling pathway involved in arterial endothelial cell fate commitment left/right axis specification nephron development proximal tubule development loop of Henle development clathrin-mediated endocytosis energy homeostasis endothelial tip cell fate specification neuronal stem cell population maintenance skin epidermis development regulation of vascular endothelial growth factor signaling pathway positive regulation of sprouting angiogenesis negative regulation of cardiac muscle cell differentiation in utero embryonic development vasculature development epithelial cell development regionalization endothelium development embryo development ending in birth or egg hatching organ morphogenesis neuron differentiation inner ear morphogenesis odontogenesis of dentin-containing tooth auditory receptor cell differentiation eye morphogenesis embryonic morphogenesis regulation of developmental growth multicellular organismal homeostasis regulation of transport negative regulation of developmental process negative regulation of multicellular organismal process epithelial tube morphogenesis renal tubule development
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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