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Invitrogen
TGFBR2 Polyclonal Antibody
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FIGURE: 1 / 2
TGFBR2 Antibody (PA5-47719) in WB
Western blot was performed using Anti-TGFBR2 Polyclonal Antibody (Product # PA5-47719) and a 65 kDa band corresponding to TGFBR2 was observed across tissue extracts tested except Mouse Tongue and Rat tongue which is reported to be low. Uncharacterized bands around 48 kDa and 20 kDa were also observed in the samples tested. Tissue extracts (30 µg lysate) of Mouse Brain (Lane 1), Rat Brain (Lane 2), Mouse Lung (Lane 3), Rat Lung (Lane 4), Mouse Tongue (Lane 5) and Rat Tongue (Lane 6) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein ... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-47719
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Published species
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse TGF-beta RII and Sf 21-derived recombinant mouse TGF-beta RII Ile24-Asp184
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
0.2 mg/mL once reconstituted
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In direct ELISAs, approximately 5% cross-reactivity with recombinant human (rh) TGF-beta RII is observed and less than 1% cross-reactivity with recombinant mouse TGF-beta RI and rhTGF-beta RIII is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Transforming Growth Factor, beta receptor 2 (AAT3, FAA3, MFS2, RIIC, LDS1B, LDS2B, TAAD2, TGFR-2, TGFbeta-RII) is a member of the TGF-beta family of receptor Serine/Threonine kinases. It is involved in the regulation of cell proliferation. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). TGFBR2 encodes the gamma subunit of the catalytic core. Alternatively spliced transcript variants encoding different isoforms have been identified. TGFBR2 also has a pseudogene on chromosome 14.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: tbetaR-II; tgf beta receptor 2; TGF-beta receptor II; TGF-beta receptor type II; TGF-beta type II receptor; TGFbeta RII; TGFBR; TGFR-2; TGFR2; transforming growth factor beta receptor type II; transforming growth factor, beta receptor II; transforming growth factor, beta receptor IIT; transforming growth factor-b type II receptor; transforming growth factor-beta receptor type II; transforming growth factor-beta type II receptor; type II TGF beta receptor; unnamed protein product
Gene Aliases: 1110020H15Rik; DNIIR; RIIDN; TbetaR-II; TbetaRII; TBR-II; TGF-beta 2; Tgfbr2T
UniProt ID: (Mouse) Q62312, (Rat) P38438
Entrez Gene ID: (Mouse) 21813, (Rat) 81810
protein kinase activity
protein serine/threonine kinase activity
transmembrane receptor protein serine/threonine kinase activity
transforming growth factor beta-activated receptor activity
transforming growth factor beta receptor activity, type II
protein binding
ATP binding
glycosaminoglycan binding
activin receptor activity, type I
kinase activator activity
mitogen-activated protein kinase kinase kinase binding
type I transforming growth factor beta receptor binding
type III transforming growth factor beta receptor binding
signaling receptor activity
SMAD binding
metal ion binding
activin binding
transforming growth factor beta binding
binding, bridging
protein homodimerization activity
macromolecular complex binding
patterning of blood vessels
vasculogenesis
in utero embryonic development
epithelial to mesenchymal transition
heart looping
positive regulation of mesenchymal cell proliferation
lens development in camera-type eye
positive regulation of tolerance induction to self antigen
positive regulation of B cell tolerance induction
positive regulation of T cell tolerance induction
outflow tract septum morphogenesis
membranous septum morphogenesis
outflow tract morphogenesis
aortic valve morphogenesis
atrioventricular valve morphogenesis
tricuspid valve morphogenesis
cardiac left ventricle morphogenesis
endocardial cushion fusion
growth plate cartilage development
growth plate cartilage chondrocyte growth
protein phosphorylation
receptor-mediated endocytosis
apoptotic process
transmembrane receptor protein serine/threonine kinase signaling pathway
transforming growth factor beta receptor signaling pathway
Notch signaling pathway
smoothened signaling pathway
gastrulation
nervous system development
brain development
heart development
positive regulation of cell proliferation
negative regulation of cell proliferation
response to xenobiotic stimulus
organ morphogenesis
regulation of gene expression
positive regulation of epithelial cell migration
positive regulation of epithelial to mesenchymal transition
lung development
activin receptor signaling pathway
response to lipid
embryonic hemopoiesis
aorta morphogenesis
regulation of cell proliferation
myeloid dendritic cell differentiation
positive regulation of angiogenesis
positive regulation of smooth muscle cell proliferation
embryonic cranial skeleton morphogenesis
artery morphogenesis
positive regulation of developmental process
positive regulation of NK T cell differentiation
cartilage development
regulation of multicellular organismal process
palate development
negative regulation of cardiac muscle cell proliferation
positive regulation of SMAD protein import into nucleus
SMAD protein signal transduction
ventricular septum morphogenesis
lung morphogenesis
bronchus development
bronchus morphogenesis
trachea morphogenesis
trachea formation
mammary gland morphogenesis
lung lobe morphogenesis
secondary palate development
response to cholesterol
cellular response to growth factor stimulus
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
cell proliferation involved in endocardial cushion morphogenesis
superior endocardial cushion morphogenesis
inferior endocardial cushion morphogenesis
lens fiber cell apoptotic process
miRNA transport
positive regulation of reactive oxygen species metabolic process
positive regulation of CD4-positive, alpha-beta T cell proliferation
regulation of stem cell differentiation
response to hypoxia
embryo implantation
response to nutrient
response to mechanical stimulus
response to glucose
organ regeneration
positive regulation of skeletal muscle tissue regeneration
response to estrogen
response to steroid hormone
digestive tract development
cellular response to acetaldehyde
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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