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Invitrogen
Nogo-B Polyclonal Antibody
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FIGURE: 1 / 2
Nogo-B Antibody (PA5-47807) in IHC (P)
Immunohistochemical analysis of Nogo-B in immersion fixed paraffin-embedded sections of human heart. Samples were incubated in Nogo-B polyclonal antibody (Product # PA5-47807) using a dilution of 3 µg/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic. Tissue was stained using the Anti-Sheep HRP-DAB ... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-47807
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CHO-derived recombinant human Nogo-B Met1-Val200
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In direct ELISAs, less than 1% cross-reactivity with recombinant human Nogo-A and recombinant rat Nogo-A is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Nogo-B is a member of the reticulon-4 (RTN4) family of proteins, primarily localized to the endoplasmic reticulum and expressed in many tissues, especially vascular endothelial and smooth muscle cells. It plays a key role in regulating vascular remodeling, cell migration, and tissue repair by influencing cytoskeletal organization and signaling pathways. Unlike Nogo-A, which is known for inhibiting nerve regeneration, Nogo-B is more involved in maintaining vascular homeostasis and modulating inflammatory responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ASY; foocen; Human NogoA; My043 protein; neurite growth inhibitor 220; neurite outgrowth inhibition; RTN4; foocen; neurite outgrowth inhibitor; neuroendocrine-specific protein C homolog; NOGO-A; RTN4-A; NOGO-B; RTN4-B1; NOGO-C; RNT4-C; NOGO-C; RTN4-C; reticulon; reticulon 5; RTN4-Aa; RTN4-Ab; RTN4-B2; RTN4-D; RTN4-E; RTN4-F; RTN4-G; RTN4; foocen; RTN4a; RTN4b; RTN4c; unnamed protein product
Gene Aliases: 1110020G17Rik; ASY; C130026I10Rik; mKIAA0886; mKIAA4153; Nbla00271; Nbla10545; NgA; NI220/250; NOGO; Nogo-A; Nogo-B; Nogo-C; NOGOA; NOGOB; NSP; NSP-CL; RTN-X; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C
UniProt ID: (Human) Q9NQC3, (Mouse) Q99P72
Entrez Gene ID: (Human) 57142, (Mouse) 68585
blastocyst formation
leukocyte migration involved in inflammatory response
endoplasmic reticulum organization
nervous system development
axonal fasciculation
brain development
positive regulation of epithelial cell migration
negative regulation of neuron projection development
cerebral cortex radial glia guided migration
central nervous system vasculogenesis
neuron differentiation
negative regulation of cell growth
regulation of cell migration
negative regulation of axon extension
positive regulation of mammary gland epithelial cell proliferation
positive regulation of dopamine secretion
positive regulation of toll-like receptor 9 signaling pathway
positive regulation of Rac protein signal transduction
cell migration involved in vasculogenesis
negative regulation of neuron differentiation
positive regulation of glial cell differentiation
positive regulation of angiogenesis
positive regulation of collateral sprouting of injured axon
negative regulation of axonogenesis
modulation of synaptic transmission
protein stabilization
nuclear pore complex assembly
positive regulation of protein kinase B signaling
regulation of nervous system development
cardiac epithelial to mesenchymal transition
positive regulation of macrophage cytokine production
protein localization to lysosome
negative regulation of neuron projection regeneration
cellular response to hypoxia
endoplasmic reticulum tubular network organization
endoplasmic reticulum tubular network assembly
cellular sphingolipid homeostasis
cell adhesion involved in sprouting angiogenesis
regulation of postsynapse assembly
negative regulation of beta-amyloid formation
positive regulation of neutrophil migration
negative regulation of dendrite extension
positive regulation of macrophage migration
positive regulation of protein localization to endoplasmic reticulum
positive regulation of ERBB3 signaling pathway
positive regulation of artery morphogenesis
negative regulation of formation of growth cone in injured axon
endoplasmic reticulum tubular network membrane organization
regulation of branching morphogenesis of a nerve
positive regulation of hepatocyte proliferation
negative regulation of vasculogenesis
apoptotic process
regulation of apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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