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Invitrogen
TSG Polyclonal Antibody
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FIGURE: 1 / 2
TSG Antibody (PA5-47933) in IHC (F)
Immunohistochemical analysis of TSG in immersion fixed frozen sections of mouse embryo. Samples were incubated in TSG polyclonal antibody (Product # PA5-47933) using a dilution of 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue). Lower panel shows a lack of labeling if primary antibodies are omitted and t... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-47933
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Sf 21-derived recombinant mouse TSG Cys25-Phe222
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
Target Information
TWSG1 may be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: involved in molecular signalling during spermatogenesis; secreted BMP-binding protein; twisted gastrulation homolog 1; unnamed protein product
Gene Aliases: 1810013J15Rik; 9030422N06Rik; D17Ertd403e; Tsg; Twg
UniProt ID: (Mouse) Q9EP52
Entrez Gene ID: (Mouse) 65960
ossification
mesoderm formation
negative regulation of cytokine production
salivary gland morphogenesis
tissue development
hemopoiesis
cell differentiation
BMP signaling pathway
regulation of BMP signaling pathway
positive regulation of transforming growth factor beta receptor signaling pathway
positive regulation of BMP signaling pathway
negative regulation of BMP signaling pathway
forebrain development
camera-type eye development
negative regulation of osteoblast differentiation
positive regulation of SMAD protein import into nucleus
negative regulation of CD4-positive, alpha-beta T cell activation
negative regulation of CD4-positive, alpha-beta T cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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