Search
Invitrogen
alpha Actinin 2/3 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-49802
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from N-terminal of human Actin alpha-2/3.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody detects endogenous levels of total alpha Actinin 2 + alpha Actinin 3 protein.
Target Information
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Actinin alpha3; Actinin-alpha3; ACTN3; alpha-actinin skeletal muscle; alpha-Actinin3; alphaActinin-3; F-actin cross-linking protein; structural protein; unnamed protein product
Gene Aliases: 1110008F24Rik; ACTN3D; CMD1AA; CMH23; CMYO8; CMYP8; MPD6; MYOCOZ
UniProt ID: (Human) P35609, (Human) Q08043, (Mouse) Q9JI91, (Mouse) O88990
Entrez Gene ID: (Human) 88, (Human) 89, (Mouse) 11472, (Rat) 291245, (Rat) 171009, (Mouse) 11474
transcription coactivator activity
integrin binding
calcium ion binding
protein binding
phosphatidylinositol-4,5-bisphosphate binding
cytoskeletal protein binding
structural constituent of muscle
protein domain specific binding
LIM domain binding
titin binding
identical protein binding
ion channel binding
actin filament binding
FATZ binding
titin Z domain binding
structural constituent of postsynaptic actin cytoskeleton
channel activator activity
protein binding, bridging
macromolecular complex binding
muscle contraction
microspike assembly
actin cytoskeleton organization
regulation of membrane potential
negative regulation of potassium ion transport
positive regulation of potassium ion transport
sarcomere organization
positive regulation of transcription, DNA-templated
focal adhesion assembly
actin filament uncapping
muscle cell development
cardiac muscle cell development
protein localization to plasma membrane
phospholipase C-activating angiotensin-activated signaling pathway
postsynaptic actin cytoskeleton organization
negative regulation of protein localization to cell surface
positive regulation of endocytic recycling
regulation of the force of skeletal muscle contraction
skeletal muscle atrophy
transition between fast and slow fiber
response to denervation involved in regulation of muscle adaptation
positive regulation of fast-twitch skeletal muscle fiber contraction
regulation of apoptotic process
negative regulation of glycolytic process
positive regulation of skeletal muscle tissue growth
positive regulation of skeletal muscle fiber development
bone morphogenesis
negative regulation of calcineurin-NFAT signaling cascade
regulation of muscle system process
negative regulation of oxidative phosphorylation
negative regulation of cold-induced thermogenesis
positive regulation of bone mineralization involved in bone maturation
negative regulation of relaxation of muscle
regulation of aerobic respiration
positive regulation of glucose catabolic process to lactate via pyruvate
cell adhesion
anatomical structure formation involved in morphogenesis
fibril organization
osteoblast differentiation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support