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Invitrogen
IRX3 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-49818
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from internal of human IRX3 (aa 271-320).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody detects endogenous levels of total IRX3 protein.
Target Information
IRX3 is a member of the Iroquois homeobox gene family (seeIRX1; MIM 606197) and plays a role in an early step of neural development. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: homeodomain protein IRXB1; iroquois homeobox protein 3; iroquois-class homeodomain protein IRX-1; unnamed protein product
Gene Aliases: IRX-1; IRXB1
UniProt ID: (Human) P78415, (Mouse) P81067
Entrez Gene ID: (Human) 79191, (Mouse) 16373
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
metanephros development
kidney development
Purkinje myocyte development
atrioventricular bundle cell differentiation
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
mesoderm development
neuron differentiation
negative regulation of neuron differentiation
positive regulation of neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
cell development
animal organ development
His-Purkinje system cell differentiation
proximal/distal pattern formation involved in nephron development
specification of loop of Henle identity
energy homeostasis
regulation of cell communication by electrical coupling involved in cardiac conduction
positive regulation of gap junction assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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