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Invitrogen
PCP4 Polyclonal Antibody
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FIGURE: 1 / 1
PCP4 Antibody (PA5-50188) in WB
Western Blot analysis of PCP4 was performed using Mouse heart tissue lysate. The membrane was probed with PCP4 Polyclonal Antibody (Product # PA5-50188) at dilution 1:500. Secondary antibody: (HRP-conjugated Goat anti rabbit IgG) at 1:5,000 dilution. Exposure time: 5 minutes.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-50188
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Fusion protein corresponding to a region derived from internal residues of human purkinje cell protein 4
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
2.3 mg/mL
Amount
230 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody detects endogenous levels of total PCP4 protein.
Target Information
PCP-4 (Purkinje cell protein 4), also known as PCP4, is a calmodulin (CaM) regulatory protein that is highly expressed in neuronal cells. Through its IQ motif, PCP-4 mediates both the calcium-dependent binding properties of CaM and the rates of association and dissociation of calcium from the C-terminal domain of CaM. The IQ motif contains a serine residue which can be phosphorylated by all isoforms of protein kinase C (PKC). PCP-4 is implicated in uterine leiomyomas, as well as in neurodegenerative disorders such as Alzheimer's disease and Huntington's disease. Additionally, overexpression of PCP-4 is thought to play a role in cerebellar hypoplasia, a key feature of Down syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: brain specific polypeptide PEP19; brain-specific antigen PCP-4; brain-specific polypeptide PEP-19; Neuron specific protein PEP-19 (Purkinje cell protein 4); neuron-specific protein PEP-19; PCP4; unnamed protein product
Gene Aliases: P16Rimb19; Pcp-4; PEP-19; Pep19; PEPZ19
UniProt ID: (Human) P48539, (Mouse) P63054, (Rat) P63055
Entrez Gene ID: (Human) 5121, (Mouse) 18546, (Rat) 25510
negative regulation of protein kinase activity
positive regulation of neuron projection development
positive regulation of dopamine secretion
negative regulation of neuron apoptotic process
positive regulation of neuron differentiation
positive regulation of CAMKK-AMPK signaling cascade
osteoblast differentiation
cellular response to L-glutamate
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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