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Invitrogen
KDM5B Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-50693
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to a region derived from internal residues of human lysine (K)-specific demethylase 5B
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
2.7 mg/mL
Amount
270 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody detects endogenous levels of total KDM5B protein.
Target Information
KDM5B is a histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. It does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. KDM5B demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. It acts as a transcriptional corepressor for FOXG1B and PAX9. It favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, KDM5B may act as a tumor suppressor for melanoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: [histone H3]-trimethyl-L-lysine(4) demethylase 5B; cancer/testis antigen 31; histone demethylase JARID1B; HRIHFB2060; jumonji, AT rich interactive domain 1B; jumonji, AT rich interactive domain 1B (Rbp2 like); jumonji/ARID domain-containing protein 1B; lysine (K)-specific demethylase 5B; protein phosphatase 1, regulatory subunit 98; putative DNA/chromatin binding motif; putative DNA/chromatin binding motif 1; retinoblastoma-binding protein 2 homolog 1; retinoblastoma-binding protein 2, homolog 1A; unnamed protein product
Gene Aliases: 2010009J12Rik; 2210016I17Rik; CT31; D1Ertd202e; JARID1B; mKIAA4034; MRT65; PLU-1; PLU1; PPP1R98; PUT1; Rb-Bp2; RBBP2H1A; RBP2-H1
UniProt ID: (Human) Q9UGL1, (Mouse) Q80Y84
Entrez Gene ID: (Human) 10765, (Mouse) 75605
chromatin remodeling
regulation of transcription, DNA-templated
cellular response to fibroblast growth factor stimulus
negative regulation of transcription, DNA-templated
response to fungicide
lens fiber cell differentiation
single fertilization
post-embryonic development
positive regulation of gene expression
positive regulation of mammary gland epithelial cell proliferation
regulation of circadian rhythm
branching involved in mammary gland duct morphogenesis
mammary duct terminal end bud growth
uterus morphogenesis
cellular response to leukemia inhibitory factor
regulation of estradiol secretion
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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