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Invitrogen
TCEB1 Polyclonal Antibody
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FIGURE: 1 / 2
TCEB1 Antibody (PA5-50802) in IHC (P)
Immunohistochemical analysis of TCEB1 in paraffin-embedded The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using (left) TCEB1 Polyclonal Antibody (Product # PA5-50802) at a 1:40 dilution and (right) is treated with fusion protein. (Original magnification: x200).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-50802
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Full length fusion protein of Human TCEB1
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
2.2 mg/mL
Amount
220 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody detects endogenous levels of total TCEB1 protein.
Target Information
TCEB1 is known as protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: elongation factor SIII p15 subunit; elongin 15 kDa subunit; RNA polymerase II transcription factor SIII subunit C; SIII p15; stromal membrane-associated protein SMAP1B homolog; transcription elongation factor B (SIII), polypeptide 1; transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C); transcription elongation factor B polypeptide 1; transcription elongation factor B subunit 1; unnamed protein product
Gene Aliases: 2610043E24Rik; 2610301I15Rik; SIII; TCEB1
UniProt ID: (Human) Q15369, (Mouse) P83940, (Rat) P83941
Entrez Gene ID: (Human) 6921, (Mouse) 67923, (Rat) 64525
transcription initiation from RNA polymerase II promoter
ubiquitin-dependent protein catabolic process
protein ubiquitination
ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
target-directed miRNA degradation
positive regulation of transcription elongation from RNA polymerase II promoter
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription from RNA polymerase II promoter
proteasome-mediated ubiquitin-dependent protein catabolic process
ribosome-associated ubiquitin-dependent protein catabolic process
negative regulation of DNA-dependent DNA replication
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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