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Invitrogen
Cdc20 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-50925
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from the Internal region of human Cdc20.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 0.5% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
CDC20 Polyclonal Antibody detects endogenous levels of CDC20 protein.
Target Information
Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDC20 cell division cycle 20 homolog; cell cycle protein p55CDC; cell division cycle 20 homolog; fizzy homolog; mmCdc20; unnamed protein product
Gene Aliases: 2310042N09Rik; bA276H19.3; CDC20A; OOMD14; OZEMA14; p55CDC
UniProt ID: (Human) Q12834, (Rat) Q62623, (Mouse) Q9JJ66
Entrez Gene ID: (Human) 991, (Rat) 64515, (Mouse) 107995
mitotic sister chromatid cohesion
positive regulation of cell proliferation
protein ubiquitination
anaphase-promoting complex-dependent catabolic process
positive regulation of synaptic plasticity
regulation of meiotic nuclear division
metaphase/anaphase transition of cell cycle
positive regulation of mitotic metaphase/anaphase transition
regulation of dendrite development
positive regulation of synapse maturation
mitotic spindle assembly
positive regulation of meiotic cell cycle process involved in oocyte maturation
positive regulation of ubiquitin protein ligase activity
positive regulation of anaphase-promoting complex-dependent catabolic process
metaphase/anaphase transition of meiosis I
G2/M transition of mitotic cell cycle
mitotic spindle assembly checkpoint
protein deubiquitination
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
regulation of mitotic cell cycle
regulation of meiotic cell cycle
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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