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Invitrogen
NUDT15 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-58614
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human NUDT15. Recombinant protein control fragment (Product #RP-102861).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.3 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: EKENYHYVTI LMKGEVDVTH DSEPKNVEPE KNESWEWVPW EELPPLDQLF WGLRCLKEQG YDPFKEDLNH LVGYKGNHL
Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 90%.
Target Information
Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear. May have a role in DNA synthesis and cell cycle progression throught the interaction with PCNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 8-oxo-dGTPase NUDT15; mutT homolog 2; nucleoside diphosphate-linked to another moiety X hydrolase 15; nudix (nucleoside diphosphate linked moiety X)-type motif 15; nudix-type motif 15; probable 7,8-dihydro-8-oxoguanine triphosphatase NUDT15; probable 8-oxo-dGTP diphosphatase NUDT15; RP11-90M2.1; unnamed protein product
Gene Aliases: MTH2; NUDT15D
UniProt ID: (Human) Q9NV35
Entrez Gene ID: (Human) 55270
protein binding
8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
dGTP diphosphatase activity
8-oxo-dGDP phosphatase activity
nucleoside-triphosphate diphosphatase activity
isoprenoid diphosphate phosphatase activity
farnesyl diphosphatase activity
mitotic cell cycle
purine nucleotide catabolic process
dGTP catabolic process
response to stress
purine deoxyribonucleoside triphosphate catabolic process
xenobiotic catabolic process
DNA protection
nucleobase-containing small molecule metabolic process
regulation of proteasomal protein catabolic process
nucleoside phosphate catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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