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Invitrogen

Phospho-IP3 Receptor 1 (Tyr353) Polyclonal Antibody

2 Published Figures
1 Reference
View all (35) IP3 Receptor 1 antibodies

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Phospho-IP3 Receptor 1 (Tyr353) Polyclonal Antibody

Product Details

PA5-64735

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human IP3 Receptor (Phospho-Tyr353)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2662549

Product Specific Information

Phospho-IP3 Receptor 1 (Tyr353) Polyclonal Antibody detects endogenous levels of IP3 Receptor 1 only when phosphorylated at Tyr353.

Target Information

Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: inositol 1,4,5 trisphosphate receptor; inositol 1,4,5-triphosphate receptor 1; inositol 1,4,5-triphosphate receptor, type 1; inositol 1,4,5-trisphosphate receptor type 1; inositol 1,4,5-trisphosphate-binding protein P400; inositol-1,4,5-triphosphate receptor; inositol-1,4,5-triphosphate receptor (alt., clone pI16); InsP>3

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Gene Aliases: ACV; CLA4; D6Pas2; Gm10429; I145TR; InsP3R; INSP3R1; IP3R; IP3R 1; IP3R1; Itpr-1; opt; P400; Pcp-1; Pcp1; PPP1R94; SCA15; SCA16; SCA29; wblo

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UniProt ID: (Human) Q14643, (Mouse) P11881, (Rat) P29994

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Entrez Gene ID: (Human) 3708, (Mouse) 16438, (Rat) 25262

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Function(s)
ion channel activity inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity calcium channel activity calcium ion binding protein binding calcium ion transmembrane transporter activity calcium-release channel activity calcium channel inhibitor activity protein domain specific binding phosphatidylinositol binding protein homodimerization activity inositol 1,4,5 trisphosphate binding inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels ATP binding protein phosphatase binding identical protein binding ion channel binding macromolecular complex binding
Process(es)
cell morphogenesis response to hypoxia ion transport calcium ion transport signal transduction phospholipase C-activating G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway single fertilization regulation of autophagy calcium-mediated signaling calcium ion transmembrane import into mitochondrion epithelial fluid transport positive regulation of apoptotic process regulation of calcium-mediated signaling negative regulation of calcium-mediated signaling release of sequestered calcium ion into cytosol protein homotetramerization regulation of cytosolic calcium ion concentration transmembrane transport intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress calcium ion transmembrane transport regulation of postsynaptic cytosolic calcium ion concentration release of sequestered calcium ion into cytosol by endoplasmic reticulum positive regulation of cytosolic calcium ion concentration post-embryonic development positive regulation of neuron projection development endoplasmic reticulum calcium ion homeostasis negative regulation of apoptotic process voluntary musculoskeletal movement positive regulation of calcium ion transport cellular response to cAMP liver regeneration positive regulation of hepatocyte proliferation dendrite development cellular response to hypoxia
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