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Invitrogen

Phospho-GRK1/GRK2 (Tyr13) Polyclonal Antibody

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Phospho-GRK1/GRK2 (Tyr13) Polyclonal Antibody

Product Details

PA5-64755

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human GRK1/2 (Phospho-Tyr13)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2665189

Product Specific Information

Phospho-GRK1/GRK2 (Tyr13) Polyclonal Antibody detects endogenous levels of GRK1/GRK2 only when phosphorylated at Tyr13.

Target Information

The sensation of sight is the result of a cascade of events starting with the interaction of photoactivated rhodopsin with a protein called transducin. Rhodopsin kinase is a G-protein-coupled Ser/Thr kinase, also known as GRK1, which is a key element in the regulation of this cascade. Following phosphorylation by GRK1, arrestin is recruited to phospho-rhodopsin quenching its phototransductive activity by preventing further interaction with transducin. By breaking the cycle of phototransduction, GRK1 plays an important role in the restoration of the system for subsequent visual events.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: adrenergic beta receptor kinase 1; adrenergic receptor kinase, beta 1; adrenergic, beta, receptor kinase 1; beta-adrenergic receptor kinase 1; beta-adrenergic receptor kinase 1 beta ARK1; beta-AR kinase-1; beta-ARK-1; G protein-coupled receptpr kinase 1; G-protein receptor kinase 1; grk 2; GRK2; RK; unnamed protein product

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Gene Aliases: Adrbk-1; ADRBK1; Bark-1; BARK1; beta ARK; BETA-ARK1; betaARK1; GPRK1; GRK-2; RHOK; RK

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UniProt ID: (Human) Q15835, (Human) P25098, (Rat) Q63651, (Mouse) Q99MK8, (Rat) P26817

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Entrez Gene ID: (Human) 6011, (Human) 156, (Mouse) 24013, (Rat) 81760, (Mouse) 110355, (Rat) 25238

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Function(s)
protein kinase activity protein serine/threonine kinase activity G-protein coupled receptor kinase activity ATP binding rhodopsin kinase activity G-protein coupled receptor binding protein binding alpha-2A adrenergic receptor binding Edg-2 lysophosphatidic acid receptor binding beta-adrenergic receptor kinase activity ubiquitin protein ligase binding delta-type opioid receptor binding kappa-type opioid receptor binding scaffold protein binding
Process(es)
regulation of the force of heart contraction desensitization of G-protein coupled receptor protein signaling pathway negative regulation of the force of heart contraction by chemical signal protein phosphorylation response to oxidative stress signal transduction G-protein coupled receptor signaling pathway tachykinin receptor signaling pathway heart development positive regulation of muscle cell apoptotic process negative regulation of peptidyl-threonine phosphorylation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation viral genome replication receptor internalization positive regulation of interleukin-6 production regulation of inositol trisphosphate biosynthetic process negative regulation of peptidyl-serine phosphorylation positive regulation of catecholamine secretion intraciliary retrograde transport vasodilation follicle-stimulating hormone signaling pathway negative regulation of apoptotic process negative regulation of G-protein coupled receptor protein signaling pathway positive regulation of smoothened signaling pathway positive regulation of vasoconstriction negative regulation of striated muscle contraction negative regulation of glucose import viral entry into host cell positive regulation of fibroblast proliferation oligodendrocyte differentiation maintenance of protein location in nucleus cardiac muscle contraction positive regulation of ERK1 and ERK2 cascade cellular response to glucose stimulus cellular response to epidermal growth factor stimulus negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway negative regulation of cellular response to insulin stimulus negative regulation of relaxation of smooth muscle negative regulation of protein localization to ciliary membrane positive regulation of vascular smooth muscle cell proliferation positive regulation of intraciliary retrograde transport cellular response to chemokine positive regulation of excitatory postsynaptic potential negative regulation of apoptotic signaling pathway visual perception photoreceptor cell morphogenesis response to light stimulus regulation of signal transduction regulation of rhodopsin mediated signaling pathway positive regulation of phosphorylation protein autophosphorylation post-embryonic retina morphogenesis in camera-type eye G-protein coupled acetylcholine receptor signaling pathway regulation of G-protein coupled receptor protein signaling pathway rhodopsin mediated signaling pathway response to xenobiotic stimulus response to muscle activity response to hydrogen peroxide response to leptin response to caloric restriction cellular response to catecholamine stimulus cellular response to rapamycin cellular response to phorbol 13-acetate 12-myristate
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